Frontiers in Catecholamine Research

Frontiers in Catecholamine Research is a collection of papers presented at the Third International Catecholamine Symposium, held at the University of Strasbourg, Strasbourg, France, on May 20-25, 1973.
This book is organized into nine parts encompassing 205 chapters. The text begins with a discussion on clinically and experimentally used drugs that have been developed or whose mechanism of action has been clarified through monoamine research. Parts II and III deal with enzymes related to catecholamine studies, their properties, regulation, genetics, mechanism of action, and localization. Parts IV and V examine the concepts of synaptic dynamics of brain regulators and the isolation, characterization, methods of analysis, and mechanism of action of catecholamines. Part VI focuses on the complexities that surround the extrapolation of catecholamine function into the realms of electrophysiology and behavior. Part VII discusses the metabolism, behavioral, neurological, and physiological effects of amphetamine and other drugs of abuse. The concluding parts describe the role of catecholamine and its metabolism in neurologic diseases, such as schizophrenia.

Contenu

Foreword

Historical

Acknowledgments

Participants

Abbreviations

I. Keynote Address

The Impact of Monoamine Research on Drug Development

II. Enzymes

Two Mechanisms of Catecholamine storage in Adrenal Chromaffin Granules

Properties of Tyrosine Hydroxylase

Cofactors of Tyrosine Hydroxylase

Characterization of dopa decarboxylase

Characterization, Localization and Regulation of Catecholamine Synthesizing Enzymes

Immunological Localisation of Dopamine-ß-Hydroxylase on the Chromaffin Granule Membrane

New Inhibitors of Microbial Origin for Dopamine-ß-Hydroxylase

Picolinic Acid Derivatives as Inhibitors of Dopamine ß-Hydroxylase In Vivo; their Effects on Blood Pressure and Stress Ulcer

The Innervation of Cerebral Blood Vessels by Central Noradrenergic Neurons

Comparative Studies on Bovine and Guinea Pig Tyrosine Hydroxylase

Regulation of Phenylethanolamine N-Methyltransferase

Catechol-O-Methyltransferase

The cellular Localization and Physiological Role of Catechol-O-Methyltransferase in the Body

Immunological Characterization of Catechol-O-Methyltransferase

New Concepts on the N-Methylation Reactions of Biogenic Amines in Adrenal Medulla and Brain

Ring Dehydroxylation of N-Methylation of Noradrenaline and Dopamine in the Intact Rat Brain

Degradation of the Transmitter Amines by Specific Types of Monoamine Oxidases

The Importance of the 'Hydroxylamine Metabolic Route' in Pharmacology, Toxicology and Pharmacokinetics

Some Characteristics of Rat Liver Mitochrondrial Monoamine Oxidases

The Nature of the Electrophoretically Separable Forms of Monoamine Oxidase

Transformation of Monoamine Oxidases and Deamination of Fattyaromatic Monoamines

On the Mechanism of Inhibition of Monoamine Oxidase

Selective Localization of Monoamine oxidase Forms in Rat Mesenteric Artery

Oxidative-Reductive Pathways for Metabolism of Biogenic Aldehydes

Sulfate Conjugates in the Brain

Reporter's Notes

First Session

Second Session

III. Regulation

Trans-synaptic Regulation of Tyrosine Hydroxylase

Modulation of Adrenal Tyrosine Hydroxylase Induction by Serotonin Nerve Function

Role of Catecholamines in Induction of Adrenal Tyrosine Hydroxylase

Dopamine-ß-Hydroxylase and the Regulation of Catecholamine Biosynthesis

Retrograde Axonal Transport of Dopamine-ß-Hydroxylase

Growth and Development of a Sympathetic Ganglion In Vivo

Studies on the Mechanism of Regulation of Tyrosine Hydroxylase Activity during Nerve Stimulation

Transsynaptic and Humoral Regulation of Adrenal Catecholamine Synthesis in Stress

Transsynaptic Regulation of Tyrosine Hydroxylasein Adrenal Medulla: Possible Role of Cyclic Nucleotides

Comment-Cholinergic Regulation of Tyrosine Hydroxylase

Sympathetic Ganglia in Culture

Lack of Relationship between Noradrenaline Content and Tyrosine Hydroxylase Activity in Cultured Sympathetic Ganglia

Induction of Tyrosine Hydroxylase in Superior Cervical Ganglion by Cold Exposure: Effects of Decentralization and Mecamylamine

Regulation of Catechol Synthesis in an Adrenergic Clone of Mouse Neuroblastoma

Development of the Central Catecholaminergic Neurons of the Rat

Interaction between the Nerve Growth Factor (NGF) and Adrenergic Blocking Agents in Sympathetic Neurons

Neuroblastoma Cells as a Tool for Neuronal Molecular Biology

Reporter's Notes

IV. Synaptic Dynamics of Receptors

The classification of Adrenergic Receptors

Antagonism of Propranolol to Isoproterenol in Guinea-Pig Trachea: Some Cautionary Findings

Regulation of Cyclic AMP Levels in Brain

Regulation of Adenosine 3',5'-Cyclic Monophosphate Metabolism in Hybrid Somatic Cells

Ontogenetic Development of the Catecholamine-Sensitive Adenyl Cyclase Activity of Rat Cerebral Cortex

Role of ß-Adrenergic Receptor in the Control of Serotonin N-Acetyltransferase in Rat Pineal

Beta-Adrenergic Regulation of Indole Metabolism in the Pineal Gland

Selective Regulation of the Multiple Molecular form of Cyclic Nucleotide Phosphodiesterase by Norepinephrine and Other Agents

StereoiSomers of Catecholamines

Effects of Catecholamines and Prostaglandins on Cyclic AMP Levels in Brain In Vivo

Development of Antibodies against Catecholamines

Metabolic Responses of Cardiac, Skeletal Muscle, and Fat Cells to Catecholamines

Methods of Approach for the Isolation of ß-Adrenergic Receptors

Toward Isolation of a ß-Adrenergic Binding Protein

Recent Advances in the Active site Chemistry of the Adrenergic Alpha-Receptor

Operation of Two Epinephrine Receptors and an Acetylcholine Receptor in the Exocrine Cell of the Rat Parotid Gland

Dopamine-, Octopamine- and Serotonin-Sensitive Adenylate Cyclases: Possible Receptors in Aminergic Neurotransmission

Comparison of the Excitatory Action of Acetylcholine and Noradrenaiine on the Guinea-Pig Myometrium

Possible Mechanism of the Action of Catecholamines on Smooth Muscle

Reporter's Notes

V Synaptic Dynamics

Chairman's remarks

Catecholamine Release and Mobilization of Protein

Neuronal and Extraneuronal Catecholamine Uptake Mechanisms

The Possible Importance of Young (large) Amine Storage Granules for Adrenergic Nerve Terminal Function

Conformational Aspects of the Inhibition of Neuronal Uptake of Noradrenaiine by Tricyclic Antidepressants

Composition and Molecular Organization of Chromaffin Granules

A Large Second Pool of Norepinephrine in the Highly Purified Vesicle Fraction from Bovine Splenic Nerve

Effect of Electrolytes on Amine Transport and Release Mechanisms in Nerve Endings

Small Intensely Fluorescent (SIF) Cells In Vivo and In Vitro

Neuronal Catecholamine Storage Vesicles

Secretion and Recovery of Catecholamines by the Adrenal Medulla

New Aspects of the Localization of Catecholamines in Adrenergic Neurons

Plastic Changes of Central Noradrenaline Neurons after 6-Hydroxydopamine

Characterization of Cortical Noradrenergic Axon Terminals with High Resolution Radioautography

Matrix Phase Organization in the Adrenal Chromaffin Granule

Release of Amines from Sympathetic Nerves

Mechanisms of Exocytosis

Immunological Studies of Dopamine ß-Hydroxylase as a Marker for Adrenergic Synaptic Vesicles

Mechanisms of Catecholamine Secretion: Dual Feedback Control of Sympathetic Neurotransmitter Secretion; Role of Calcium

The Effect of Transmitter Release on the Dopamine ß-Hydroxylase Content of Sympathetic …