From Ion Channels to Cell-to-Cell Conversations

Ion channels allow us to see nature in all its magnificence, to hear a Bach suite, to smell the aroma of grandmother's cooking, and, in this regard, they put us in contact with the external world. These ion channels are protein molecules located in the cell membrane. In complex organisms, cells need to communicate in order to know about their metabolic status and to act in a coordinate manner. The latter is also accomplished by a class of ion channels able to pierce the lipid bilayer membranes of two adjacent cells. These intercellular channels are the functional subunits of gap junctions. Accordingly, the book is divided in two parts: the first part is dedicated to ion channels that look to the external world, and the second part is dedicated to gap junctions found at cell interfaces. This book is based on a series of symposia for a meeting on ion channels and gap junctions held in Santiago, Chile, on November 28-30, 1995. The book should be useful to graduate students taking the first steps in this field as well as a reference for the aficionado. The aim of the meeting was mainly to show the impact of various modern techniques, including cell biology, molecular biology, biophysics, and molecular­ genetics techniques in the study of these ubiquitous intrinsic membrane proteins. Molecular-genetics techniques paved the road to the manipulation of the channel­ forming molecules.

Contenu

Ion Channels in Contact with the External World. The Ways That Ion Channels Open. The Molecular Origin of Voltage Dependence in Ionic Channels; F. Bezanilla, et al. The Conduction Mahcinery of K+ Channels. Thermodynamics of Double Mutant Cycles with the Shaker K+ Channel from the Sea Urchin Sperm in the Speract; P. Labarca, et al. Ion Channels and Volumen Regulation. Anion Channels Involved in Volumen Regulation: A Common Pathway for Chloride and Organic Osmolyte?; A. Stutzin, et al. Signal Transduction. Inhibitory Responses to Odorants in Vertebrate Olfactory Neurons; J. Bacigalupo, et al. Intercellular Channels. Ion Channels that Allow Cells to Gossip. Structure and Function of Cell-to-Cell Channels Purified from the Lens and Hemichannels Expressed in Oocytes; G. Zampighi, et al. Regulation of Gap Junctions. Gap Junctions between Leukocyte and Endothelium: Expression of Connexin 43 in Adherent or Activated Cells; M.P. Boric, et al. Functional Aspects of Gap Junctions. 20 Additional Articles. Index.