Nucleic Acids and Molecular Biology

Molecular biology is one of the most rapidly growing develo- ping and at thesame time most exciting disciplines. The key to molecular biology lies in the understanding of nucleic a- cids - their structure, function, and interaction with pro- teins. Nucleic Acids and Molecular Biology keeps scientists informed of the explosively growing information and complies with with the great interest in this field by offering a continued high standard of review. A substantial part of this volume has been devoted to the analysis of different aspects of nucleic acid-protein-interactions including RNA- protein-interaction.

Contenu

DNA, cis-Platinum and Intercalators: Catalytic Activity of the DNA Double Helix.- Indirect Effects of DNA Sequence on 434 Repressor-DNA Interactions.- E. coli Met Repressor: DNA Recognition by ?-Strands.- Mechanism of Action of Restriction Endonuclease EcoRV.- DNA Bending by Fos and Jun: Structural and Functional Implications.- Structure of the TFIIIA-DNA Complex.- Structure and Function of the Glucocorticoid Receptor DNA-Binding Domain.- Retinoid Receptors and Their Role in Cellular Proliferation and Differentiation.- Structural and Functional Aspects of the DNA Binding Protein FIS.- LexA, the Self-Cleaving Transcriptional Repressor of the SOS System.- Resolution of Holliday Junctions by the E. coli RuvC Protein.- Site-Specific Recombination and the Segregation of Circular Chromosomes.- Nucleosome Positioning.- The Role of the Nucleoskeleton in RNA Metabolism.- The Mechanism of Action of the Retinoblastoma Gene Product.- RNA Pseudoknots.- Selection of Functional RNA and DNA Molecules from Randomized Sequences.- Structure and Function of Ribonuclease HI from Escherichia coli.- RNA-Protein Interactions in Ribonucleoprotein Particles.- Hybrid States of tRNA During Translation.