Ultrastructural Pathology of the Cell and Matrix

Ultrastructural Pathology of the Cell and Matrix: Third Edition Volume I present a comprehensive examination of the intracellular lesion. It discusses the analysis of pathological tissues using electron microscope. It addresses the experimental procedures made on the cellular level.
Some of the topics covered in the book are the physiological analysis of the nucleus; nuclear matrix, interchromatin, and perichromatin granules; structure and function of centrioles; characteristics of mitochondria; Golgi complex in cell differentiation and neoplasia; and degranulation of rough endoplasmic reticulum. The intracytoplasmic and intranuclear annulate lamellae are fully covered. An in-depth account of the classification, history, and nomenclature of lysosomes are provided. The morphology and normal variations of melanosomes and anchoring fibrils are completely presented. A chapter is devoted to the endocytotic structures and cell processes. Another section focuses on the classification and nomenclature of fibrous components.
The book can provide useful information to cytologists, scientists, students, and researchers.

Contenu

Preface to the Third Edition
Preface to the Second Edition
Preface to the First Edition
Acknowledgments
1 Nucleus
Introduction
Nuclear Shape
Cerebriform Nucleus
Radially Segmented Nucleus
Chromatin in Normal, Neoplastic and Necrotic Cells
The Nuclear Matrix and Interchromatin and Perichromatin Granules
Giant Perichromatin Granules
Nuclear Envelope and Pores
Thickening, Proliferation and Reduplication of Nuclear Envelope
Evaginations or Blebs of Nuclear Envelope
Nuclear Fibrous Lamina
Nucleolus, Structure and Variations in Size, Shape and Numbers
Meandering Nucleolus
Nucleolar Margination
Segregation of Nucleolar Components
Pseudoinclusions and True Inclusions
Intranuclear Russell Bodies
Intranuclear Concentric Laminated Inclusions
Intranuclear Helioid Inclusions
Intranuclear Membranous Lamellae, Tubules and Vesicles
Intranucleolar Membranous Lamellae, Tubules and Vesicles
Intranuclear Glygogen Inclusions
Intranuclear Lipid Inclusions
Intranuclear Filamentous and Crystalline Inclusions
Intranuclear Haemoglobin Inclusions
Intranuclear Lead Inclusions
Intranuclear Bismuth Inclusions
Intranuclear Viral Inclusions and Virus-like Particles
Nuclear Projections, Pockets, Loops, Satellites and Clefts
Nuclear Bodies
References
2 Centrioles
Introduction
Structure and Function
References
3 Mitochondria
Introduction
Mitochondrial Morphology and Enzyme Content
Concentration of Cristae
Lamellar, Tubular and Vesicular Cristae
Concentric Cristae
Zig-Zag Cristae
Fenestrated Cristae
Longitudinally Orientated Cristae
Prismatic Cristae
Sinuous Undulating and Reticular Cristae
Mitochondriogenesis
Mitochondrial Involution and Elimination
Mitochondrial Associations
Intermitochondrial Herniations, Whorls and Bridges
Variations in Dense Granules and Calcification
Swollen or Hydropic Mitochondria
Flocculent or Woolly Densities in Mitochondria
Mitochondrial Hypertrophy and Hyperplasia
Mitochondria in Oncocytes and Oncocytomas
Giant Mitochondria
Ring-Shaped and Cup-Shaped Mitochondria
Chondriospheres
Mitochondrial Changes in Neoplasia
Intramitochondrial Glycogen Inclusions
Intramitochondrial Lipidic Inclusions
Intramitochondrial Crystalline, Paracrystalline and Filamentous Inclusions
Intramitochondrial Iron Inclusions
References
4 Golgi Complex and Secretory Granules
Introduction
Structure and Function
Golgi Complex in Cell Differentiation and Neoplasia
Hypertrophy and Atrophy of Golgi Complex
Lipid and Lipoprotein in Golgi Complex
Mucous Granules in Normal and Neoplastic Cells
Serous and Zymogen Granules in Normal and Neoplastic Cells
Secretory Granules (Myelinosomes) in Normal and Neoplastic Type II Alveolar Cells
Neuroendocrine (APUD) Granules and Uranaffin Reaction in Normal and Neoplastic Cells
Neuroendocrine Granules in Normal and Neoplastic Pancreatic Neuroendocrine Cells
Neuroendocrine Granules in Carcinoids
Adrenaline and Noradrenaline Granules in Normal and Neoplastic Cells
Misplaced Exocytosis
Amphicrine Cells and Amphicrine Tumours
Granules of Mast Cells and Basophilic Leucocytes
References
5 Endoplasmic Reticulum
Introduction
Rough Endoplasmic Reticulum
Smooth Endoplasmic Reticulum
Dilatation and Vesiculation of Endoplasmic Reticulum Due to Ingress of Water
Dilatation and Vesiculation of Rough Endoplasmic Reticulum Due to Storage of Secretory Products
Degranulation of Rough Endoplasmic Reticulum
Disaggregation of Polyribosomes
Helical Polyribosomes and Ribosome Crystals
Ribosome-Lamella Complex
Endoplasmic Reticulum and Ribosomes in Cell Differentiation and Neoplasia
Hypertrophy of Rough Endoplasmic Reticulum
Hypertrophy of Smooth Endoplasmic Reticulum in Hepatocytes
Confronting Cisternae
Tubular Confronting Cisternae
Confronting Cisternae Complex
Tubule Group: Rough and Smooth Tubular Aggregates and Intracisternal Tubules
Microtubule Group: Ordered Arrays of Straight Microtubules and Randomly Oriented Microtubules in Rough Endoplasmic Reticulum
Microtubule Group: Parallel Microtubular Arrays
Microtubule Group: Microtubuloreticular Structures (Lupus Type and Others)
Membrane Group: Reticulated, Knotted, Undulating, Pouched, Radiate and Cross-Banded Membranous Formations or Complexes
Membrane Group: Concentric Membranous Bodies of the Endoplasmic Reticulum
Glycogen in Rough Endoplasmic Reticulum
Lipid in Endoplasmic Reticulum (Liposomes)
Proteinaceous Granules and Crystalline Inclusions in Rough Endoplasmic Reticulum
Laminated Inclusions in Rough Endoplasmic Reticulum
Intracisternal Sequestration
Virus in Endoplasmic Reticulum
References
6 Annulate Lamellae
Introduction
Intracytoplasmic and Intranuclear Annulate Lamellae
References
7 Lysosomes
Introduction (History, Classification and Nomenclature)
Heterolysosomes and Autolysosomes
Lamellar Cup-Shaped Lysosomes
Multivesicular Bodies and R-Bodies
Lipofuscin (Residual Bodies)
Myelinoid Membranes, Myelin Figures and Myelinosomes
Erythrophagosomes and Erythrophagolysosomes
Siderosomes, Haemosiderin and Ferritin
Lysosomes and Residual Bodies in Tumors
Lysosomes in Erythrocytes
Lysosomes in Neutrophil Leucocytes
Lysosomes in Eosinophil Leucocytes
Lysosomes in Monocytes and Macrophages
Lysosomes in Melanosis Coli and Some Other Melanoses
Lysosomes in Melanosis Duodeni
Lysosomes in Malakoplakia
Lysosomes in Granular Cell Tumors
Lysosomes in Rheumatoid Arthritis
Lysosomes in the Liver of the Tumor-Bearing Host
Angulate Lysosomes
Lysosomes in Mucopolysaccharidoses
Lysosomes in Metachromatic Leucodystrophy (Sulphatoidosis)
Curvilinear Bodies in Lysosomes
Collagen in Lysosomes
Glycogen in Lysosomes (Glycogenosomes)
Metals in Lysosomes
Aurosomes
Platinosomes
Interlysosomal Crystalline Plates (Zipper-like Structures)
References
8 Microbodies (Peroxisomes, Microperoxisomes and Catalosomes)
Introduction
Structure and Normal Variations
Pathological Variations in Size, Shape and Numbers
References
9 Melanosomes
Introduction
Morphology and Normal Variations
Alterations in Melanosomes in Melanomas and Pigmentary Disorders
Granular Melanosomes
Balloon Melanosomes
Giant Melanosomes
Melanosome-Producing and Melanosome-Containing Cells in Tumors
References
10 Rod-Shaped Microtubulated Bodies
Introduction
Structure, Distribution and Variations
Rod-Shaped Microtu…