Fatal Attractions: Protein Aggregates in Neurodegenerative Disorders

Contenu

The Role of alpha-Synuclein in Parkinsons Disease: A Biophysical Analogy to Abeta and Alzheimers Disease.-Purification of Lewy Bodies and Identification of alpha-Synuclein as a Major Component of Lewy Bodies.-Mutational Analysis of Tau in Chromosome 17-Linked Dementia.-Missense and Splice Site Mutations in Tau Associated with FTDP-17: Multiple Pathogenic Mechanisms.-Tau Mutations: Genetics and Pathogenetic Mechanisms.-Tauopathies and alpha -Synucleinopathies.-Distinct Tau Gene Mutations Induce Specific Dysfunctions/Toxic Properties in Tau Proteins Associated with Specific FTDP-17 Phenotypes.-Neurodegenerative Disorders with Tauopathies: Mad Tau Diseases?.-Tau Protein: Role in Intracellular Traffic and Development of Cell Polarity.-Subject Index