Experimental Models of Infection, Inflammation and Injury

Experimental Models of Infection, Inflammation and Injury, Volume 168 provides step-by-step protocols for scientific researchers to effectively utilize experimental model systems. Chapters in this new release include Induction and Evaluation of Murine T Cell Transfer Colitis, Modelling acute graft-versus-host disease (aGVHD) in murine bone marrow transplantation (BMT) models with MHC disparity, Mouse models of Graft-Versus-Host Disease, Preclinical Model of Multiple Sclerosis: Methods in Autoimmune Demyelination, Preclinical model of Multiple Sclerosis: focal, chemical or demyelination, Investigating demyelination, efficient remyelination and remyelination failure in organotypic cerebellar slice cultures: workflow and practical tips, and more.

Other notable sections cover Rheumatoid Arthritis: Methods for Two Murine Models, Induction of Pancreatitis in Mice with Susceptibility to Pancreatic Cancer, Small Animal Models of Thermal Injury, Large Animal Models of Thermal Injury, Small animal models of localized heart irradiation, Methods for Induction and Assessment of Intestinal Permeability in Rodent Models of Radiation Injury, and more.

• Provides precise, step-by-step guidance on how to implement experimental systems
• Presents a comprehensive background on the disease the model is being used to study
• Offers insights into how the described disease models compare to other existing systems

Contenu

1. Induction and evaluation of murine colitis induced by T cell transfer Suchandrima Saha, Ji Dong K Bai, David C. Montrose
2. Modeling acute graft-versus-host disease (aGVHD) in murine bone marrow transplantation (BMT) models with MHC disparity Jasmin Scheurer, Frank Leithäuser, Klaus-Michael Debatin and Gudrun Strauss
3. Mouse models of graft-versus-host disease Dilan A. Patel, Mark A. Schroeder, Jaebok Choi and John F. DiPersio
4. Preclinical model of multiple sclerosis: Methods in autoimmune demyelination Jillian C. Nissen and Stella E. Tsirka
5. Preclinical model of multiple sclerosis: Focal, chemical or viral demyelination Stella E. Tsirka and Jillian C. Nissen
6. Investigating demyelination, efficient remyelination and remyelination failure in organotypic cerebellar slice cultures: Workflow and practical tips Rianne P. Gorter, Naomi S. Dijksman, Wia Baron and Holly Colognato
7. Rheumatoid arthritis: Methods for two murine models Aisha M. Mergaert, Thomas F. Warner and Miriam A. Shelef
8. Induction of pancreatitis in mice with susceptibility to pancreatic cancer Sarah B. Gitto, Sai Preethi Nakkina, Jordan M. Beardsley, Jignesh G. Parikh and Deborah A. Altomare
9. Small animal models of thermal injury Roohi Vinaik, Ayesha Aijaz and Marc G. Jeschke
10. Large animal models of thermal injury Ayesha Aijaz, Roohi Vinaik and Marc G. Jeschke
11. Small animal models of localized heart irradiation Marjan Boerma, Vijayalakshmi Sridharan, Kimberly J. Krager and Snehalata A. Pawar
12. Methods for induction and assessment of intestinal permeability in rodent models of radiation injury Laura E. Ewing, Prabath G. Biju, Rupak Pathak, Stepan Melnyk, Martin Hauer-Jensen and Igor Koturbash
13. Methods and protocols for translatable rodent models of postsurgical pain James W. Morgan, Sarah D. Pennypacker, E. Alfonso Romero-Sandoval and Miriam M. Fonseca
14. Methods and protocols for chemotherapy-induced peripheral neuropathy (CIPN) mouse models using paclitaxel Sarah D. Pennypacker, Miriam M. Fonseca, James W. Morgan, Patrick M. Dougherty, Juan R. Cubillos-Ruiz, Roy E. Strowd and E. Alfonso Romero-Sandoval
15. The use of foodborne infection to evaluate bacterial pathogenesis and host response Timothy H. Chu, Zhijuan Qiu and Brian S. Sheridan
16. Methods to evaluate virus-mediated acute lung inflammation Hannah M. Ivester, Juselyn D. Tupik, Margaret A. Nagai-Singer, Sheryl L. Coutermarsh-Ott and Irving C. Allen
17. Induction and analysis of systemic C. albicans infections in mice David Frank and Nick Carpino