Engineering of Micro/Nano Biosystems

This tutorial book offers an in-depth overview of the fundamental principles of micro/nano technologies and devices related to sensing, actuation and diagnosis in fluidics and biosystems. Research in the MEMS/NEMS and lab-on-chip fields has seen rapid growth in both academic and industrial domains, as these biodevices and systems are increasingly replacing traditional large size diagnostic tools. This book is unique in describing not only the devices and technologies but also the basic principles of their operation.

The comprehensive description of the fabrication, packaging and principles of micro/nano biosystems presented in this book offers guidance for researchers designing and implementing these biosystems across diverse fields including medical, pharmaceutical and biological sciences. The book provides a detailed overview of the fundamental mechanical, optical, electrical and magnetic principles involved, together with the technologies required for the design, fabrication and characterization of micro/nano fluidic systems and bio-devices.

Written by a collaborative team from France and Korea, the book is suitable for academics, researchers, advanced level students and industrial manufacturers.

Auteur

Dr. HDR. Grégory Barbillon completed his PhD in Physics (2007) with greatest distinction at the University of Technology of Troyes (France). Then, he obtained his Habilitation (HDR) in Physics (2013) at the University of Paris Sud (Orsay, France). From September 2017, he is Professor of Physics at the Faculty of Engineering "EPF - Ecole d'Ingénieurs" (Sceaux, France). His research interests are focused on Plasmonics, Nano-Optics, Non-Linear Optics, Nanophotonics, Condensed Matter Physics, Optical Sensing, Biosensing, Nanotechnology, Surface Enhanced Spectroscopies, Sum Frequency Generation Spectroscopy, Materials Chemistry, Physical Chemistry, Fluorescence.

Dr. Alain Bosseboeuf received in 1980 a master degree in microelectronics from INPG and a telecommunication engineer diploma from ENSTBr and in 1981 a master degree in Solid State Physics from University Paris 6. He received in 1989 the state PhD degree in Physics from University Paris Sud (Orsay). Since 1983 he works as a CNRS full-time researcher first in Institut d'Electronique Fondamentale (IEF) and since june 2016 in Centre for Nanoscience and nanotechnology (C2N) a joint research institute of CNRS and University Paris-Sud. He worked for 10 years on thin film deposition and characterization and then in the field of micro/nanosystems. He led for 10 years the research group NanoBio and Micro/nanosystems of IEF. He belonged to various expert, steering and conference committees in the field of microsystems. Since November 2005, he is coordinating the international research network NAMIS (Nano and Microsystems) involving 12 partners from 10 countries and 3 continents. His current interests include thin films, MEMS and packaging technologies, and the development of associated characterisation tools.

Prof. Kukjin Chun received the B.S.degree in Electronics Engineering from Seoul National University in 1977 and the M.S. and Ph.D. degrees in Electrical Engineering from the University of Michigan in 1981 and 1986, respectively. He was an Assistant Professor in the Department of Electrical and Computer Engineering at Washington State University from 1986 to 1989. He joined the faculty of Seoul National University in 1989, where he is currently a Professor in the School of Electrical Engineering. He is a senior member of IEEE and a life member of IEEK. He has been a director of the Center for Advanced Transceiver System since 2000, which develops RF front-end solution for next-generation wireless communication systems. His research interests include integrated sensors, intelligent microsystems, and MEMS processing technologies.

Prof. Rosaria Ferrigno received her PhD in Electrochemistry (1998) from the Swiss Federal Institute of Lausanne. She joined the faculty of University of Lyon in 2003, where she is currently Professor in the Electrical Engineering Department. Her research interests include Lab-on-a-Chip, Point-of-Care devices and microfluidics science with the main target to develop new in-vitro diagnostic devices.

Prof. Français Olivier received his PhD in applied physics (1998) from ENS- Cachan (France). He joined ESIEE-Paris (Marne la Vallée, France) from 1998 to 2004 to work on MEMS devices. In 2004, he had been recruited as an Assistant Professor at CNAM (Paris, France) and achieved projects on resonant sensors and microfluidics. In 2009, he joined ENS-Cachan to develop research and teaching around Microfluidics and BioMEMS. He focused his activity around cell biochips and biomimetic devices. He became specialised on study of interaction between electric fields and biological cells. In 2016, he got a full professor position at ESIEE-Paris engineering school in the biotechnology department. He is in charge for the development of microfluidics and its application towards biological applications.

Contenu

Chapter 1. Introduction

Chapter 2. Basics of micro/nano fluidics and biology 2.1 Introduction

2.2 Fluidics at micro/nano scale

2.3 Biomolecular interactions

2.4 Micro Particle Image Velocimetry technique

2.5 Main ex-situ characterization techniques for bio-devices

References

Chapter 3. Micro/nano Fabrication and packaging technologies for biosystems 3.1 Introduction

3.2 Micro/nano fabrication for fluidic devices

3.3 Surface biofunctionalization engineering for bioreceptors and antifouling coating

3.4 Packaging technologies for fluidics and biodevices

Chapter 4. Mechanics for fluidics and bio devices

4.1 Introduction

4.2 Mechanical microcomponents for fluidics

4.3 Passive microfluidics

4.4 Mechanics for bio devices

References

Chapter 5. Optics and fluidics

5.1 Introduction

5.2 Integration of optics in biodevices

5.3 Optofluidics

Chapter 6 Electricity for fluidics and biodevices

6.1 Introduction

6.2 Micro- and Nano- scale electrokinetics

6.3 Electrostatics for biodevices : dielectrophoresis

6.4 RF and microwaves for fluidics and bio devices

References

Chapter 7. Magnetophoresis in bio-devices

7.1 Introduction

7.2 Magnetism principles for magnetophoresis

7.3 Magnetic micro- or nano-object transport in magnetophoretic system

7.4 Implementation of magnetophoresis in microsystems

7.5 Magnetophoretic functions dedicated to bio-analysis

7.6 Conclusion

Chapter 8 conclusion