Endothelial Dysfunction and Inflammation

Endothelial dysfunction is broadly defined as a disruption of the balance between vasoactive mediators and a propensity towards an inflammatory state. This volume provides an overview of the fields of endothelial dysfunction and inflammation through the discussion of topics ranging from the molecular biology of activated endothelial cells to the endothelium in inflammatory disease and therapeutic approaches targeting endothelial dysfunction. Topics include: - Heterogeneity of the endothelium during inflammation - Oxidative stress and endothelial dysfunction - Biology and regulation of nitric oxide in inflammatory pathologies - Endothelial dysfunction in inflammatory diseases, such as diabetes and atherosclerosis - Clinical methods used to assess endothelial function This book brings together basic and clinical research to assist the reader in bridging connections from bench-to-bedside. Written by expert researchers in the fields of endothelial biology, inflammation research and clinical science, it serves as a useful reference for academic and industrial researchers, clinicians, and trainees in the medical profession.

Contenu
Endothelial activation and dysfunction in sepsis.- Heterogeneity in responses of microvascular endothelial cells during inflammation.- Oxidative stress and endothelial dysfunction.- Post-translational regulation of eNOS activity in inflammation.- Endothelial dysfunction in pulmonary hypertension.- Endothelial dysfunction in systemic hypertension.- Sphingosine-1-phosphate as a mediator of endothelial dysfunction during inflammation.- Dissecting TNF-TNFR1/TNFR2 signaling pathways in vasculature.- AGE-RAGE signalling in endothelial dysfunction and atherosclerosis in diabetes.- Regional predisposition to atherosclerosis An interplay between local hemodynamics, endothelial cells and resident intimal dendritic cells.- Inflammation and endothelial dysfunction with aging.- Clinical approaches to assess endothelial function in vivo.- Therapeutic approaches towards targeting endothelial dysfunction.