Endogenous ADP-Ribosylation

This volume gathers the latest exciting findings on ADP-ribosylation from renowned experts in the field. It includes ten chapters, organized into the following three thematic sections:

· Evolution and detection of endogenous ADP-ribosylation

· ADP-ribosylation by the ARTC family of ADP-ribosyltransferases (R-S-E ARTs)

· ADP-ribosylation by the ARTD family of ADP-ribosyltransferases (H-Y-E ARTs)

The book will provide readers a better understanding of ADP-ribosylating toxins and their endogenous relatives. This provides a basis for developing novel toxin-neutralizing drugs and drugs targeting endogenous ADP-ribosyltransferase relatives.

Auteur
Friedrich Koch-Nolte is a professor at University Hospital Hamburg-Eppendorf, Institute for Immunology, Hamburg, Germany

Contenu

The natural history of ADP-ribosyltransferases and the ADP ribosylation system.- Identification and Analysis of ADP-ribosylated Proteins.- Photorhabdus luminescens toxins TccC3 and TccC5: Insecticidal ADP-ribosyltransferases that modify threonine and glutamine.- Reaction mechanism of mono-ADP-ribosyltransferase based on structures of the complex of enzyme and substrate protein.- Regulation of nitrogenase by reversible mono-ADP-ribosylation.- ADP-ribosylation of P2X7: a matter of life and death for regulatory T cells and natural killer T cells.- Pierisins and CARP-1: ADP-ribosylation of DNA by ARTCs in butterflies and shellfish.- Comparative structural analysis of the putative mono-ADP-ribosyltransferases of the ARTD/PARP family.- Function and regulation of the mono-ADP-ribosyltransferase ARTD10.- Regulation of nucleocytoplasmic transport by ADP-ribosylation: the emerging role of karyopherin-1 mono-ADP-ribosylation by ARTD15.