Endocytosis and Signaling

This book focuses on the context dependency of cell signaling by showing how the endosomal system helps to structure and regulate signaling pathways. The location and concentration of signaling nodes regulate their activation cycles and engagement with distinct effector pathways. Whilst many cell signaling pathways are initiated from the cell surface, endocytosis provides an opportunity for modulating signaling networks' output.

In this book, first a series of reviews describe the endocytic and endosomal system and show how these subcellular platforms sort and regulate a wide range of signaling pathway components and phenotypic outputs. The book then reviews the latest scientific insights into how endocytic trafficking and subcellular location modulate a set of major pathways that are essential to normal cellular function and organisms' development.

Contenu

Preface

Ian Prior and Christophe Lamaze

Chapter 1 The endosomal network: mediators and regulators of endosome maturation

Maria Podinovskaia, Anne Spang

Chapter 2 Integration of the endocytic system into the network of cellular functions

Noga Budick-Harmelin, Marta Miaczynska

Chapter 3 GTPases Rac1 and Ras signaling from endosomes

Francesc Tebar, Carlos Enrich, Carles Rentero,Thomas Grewal

Chapter 4 ESCRT and membrane protein ubiquitination

Simona M. Migliano, David Teis

Chapter 5 Retromer and it's role in regulating signaling at endosomes

Matthew N.J. Seaman

Chapter 6 The lysosome and intracellular signaling

Geoffrey G. Hesketh, Lena Wartosch, Luther J. Davis, Nicholas A. Bright, J. Paul Luzio

Chapter 7 Interplay of endocytosis and growth factor receptor signaling

Rachel Moore, Marta Giralt Pujol, Zhou Zhu, Elizabeth Smythe

Chapter 8 Role of the endocytosis of caveolae in intracellular signaling and metabolism

Olivia Muriel, Miguel Sánchez-Álvarez, Raffaele Strippoli, Miguel Angel del Pozo

Chapter 9 EGFR trafficking in physiology and cancer

Giusi Caldieri*, Maria Grazia Malabarba, Pier Paolo Di Fiore, Sara Sigismund*

Chapter 10 Evolving view of membrane trafficking and signaling systems for G protein-coupled receptors

Silvia Sposini, Aylin C. Hanyaloglu

Chapter 11 Endosomal trafficking during mitosis and Notch-dependent asymmetric division

Alicia Daeden, Marcos Gonzales-Gaitan