Cell Biology and Immunology of Leukocyte Function is a collection of papers presented at the 12th International Leukocyte Culture Conference, held in Beersheba, Israel on June 1978. This book is organized into seven parts encompassing 111 chapters. The contributors cover the different aspects of cell biology and immunology and the unique leukocyte function.
Part I describes the mechanism of lymphocyte activation, the structure and function of the plasma membrane, and the macromolecular synthesis during lymphocyte activation. This part also deals with the interaction of lymphocytes with mitogenic lectins, the comparison of the mitogenic and nonmitogenic lectin binding, and the role of macrophages in the response of lymphocytes to lectins. Part II explores the thymic factors and the development of characteristic markers, antigens, and receptors. This part particularly emphasizes lymphocyte differentiation. Parts III and IV examine the genetic control and intercellular interactions involved in leukocyte function and the parameters of the immune response under in vitro conditions. Chapters on cytotoxicity, the mechanisms of phagocytic killing, autoimmunity, and the responses of leukocytes to tumor cells are included in these parts. Part V discusses the interactions of viruses and leukocytes and provides data on the physical mapping and analysis of sarcoma and leukemia viruses, while Part VI considers the application of leukocyte culture to problems of clinical medicine. Part VII involves the study of radiation effects, with an emphasis on the application of total lymphoid irradiation to the induction of transplantation tolerance. This part also looks into the role of the DNA repair process.
Cell biologists, immunologists, and biomedical scientists and researchers will greatly benefit from this book.

Contenu

Participants
Preface
Acknowledgments
Chapter I Lymphocyte Activation
Section 1 Plasma Membrane Structure and Function
The Lymphocyte Membrane and the Cytoskeleton
Triggering Signals for T-Cell Activation
Studies of Lymphocyte Activation
Functional Organization of the Lymphocyte Plasma Membrane Relating to Cell Activation
Investigations on the Role of Ca2+ as a Potential Second Messenger for T and B Lymphocyte Activation and Its Relevance in DNA Synthesis
A Model for the Control of Potassium Transport in PHA-Stimulated Human Blood Lymphocytes
Effect of Con A on the Cation Affinity of the Na+-K+- Pump in Lymphocytes
Activation of Lymphocytes without Mitogen by Increasing the Calcium Content in the Cell Culture Medium
Workshop Report: Membrane Mechanisms in Lymphocyte Activation
Section 2 Macromolecular Synthesis
Synthesis and Processing of RNA in Stimulated Fibroblasts and Lymphocytes
Regulation of Protein Synthesis during Lymphocyte Activation by Phytohaemagglutinin
Evidence for and against Unusual Species of DNA in Lymphocyte Activation
Studies on mRNA in Resting and Growing Lymphocytes
V- and C-Parts of Immunoglobulin a-Chain Genes Are Separate in Myeloma
Evidence of a Nonmessenger RNA which Is Rate Limiting for Protein Synthesis in Resting Lymphocytes
Adenylate Cyclase in Normal and Leukemic Human
Section 3 Action of Mitogens
On the Commitment of Lymphocytes to DNA Replication: A Possible Role for Transglutaminase
Cooperation Requirements of Mitogen-Stimulated Lymphocytes in Agarose- Gel Cultures
Lectin-Binding Surface Proteins of Human T-Lymphocytes: A Comparison between Mitogenic and Nonmitogenic Lectins
Parallel Induction of T-Cell Stimulation: Positive Control of T-Cell Response by Mitogen-Tested Macrophages
Chapter II Lymphocyte Differentiation
Section 1 Thymic Factors
Biological Activities and Site of Action of the Circulating Thymic Factor
Recent Developments in the Classification and Bioassay of Thymosin Polypeptides
Correlation between the Cellular Levels of cAMP Cell-Mediated Immunocompetence and the Thymic Humoral Factor (THF)
Immunoregulation by Thymopoietin and Bursopoietin (Abstract)
In Vitro Effect of Thymic Epithelial Culture Supernatant (TES) on T-Cell Markers and Functions
T-Thymus-Dependent Human Serum Factor Active on Precursors of Mature T Cells
Delineation of Separate Populations of Precursor T and B Cells in the Avian Embryo
Induction of B- and T-Cell Differentiation by Chicken Bursa and Thymus Reticular Epithelial Cells
The Role of Prothymocytes and the Thymic Microenvironment in the Pathogenesis of Thymic Lymphomas
Workshop Report: Thymic Hormones
Section 2 Surface Antigen Receptors and Markers
The Differences in Structure between Secreted and Cell Surface Membrane Immunoglobulins
Isolation and Chemical Characterization of the Active Site of A Lymphocyte Fc Receptor
Membrane Locking and the Tolerant B Cell
Biological Function and Migratory Behavior of T-Lymphocytes Mediating Delayed Type Hypersensitivity Depend on the Oxidation/Reduction State of Membrane Carbohydrates
Is Serological Polymorphism of Human DR Antigens Determined by Structural Differences in the Small (B) Chain?
Reduced Binding of Ouabain by Chronic Lymphocytic Leukemia Lymphocytes
Heterogeneity of T-Cell Surface Markers and Terminal Transferase of AKR Lymphomas: A Clue to Functional Heterogeneity
Workshop Report: Leukocyte Markers and Receptors
Chapter III Genetic Control and Intercellular Interactions
Section 1 Genetics
Alloactivation of T Lymphocytes: Alternative Pathways
Why Associative Recognition?
Role of the Light Chain in Studies of Linkage of Genes Controlling Idiotype and Heavy Chain Allotype
A Molecular Interaction Model for Ir Gene Complementation
I-Region Control of the Activity of Allogeneic Effect Factor
Section 2 Intercellular Cooperation
The Influence of Macrophage IR Gene Function on T and B Lymphocyte
The Interaction between Initiator and Recruited T-Lymphocytes
Cell-Mediated Cytotoxicity to Trinitrophenyl-Modified Autologous Cells in Mice and Men
Ia Antigens on Suppressor, Amplifier, and Helper T Cells
The Role of the I-Region in the Control of Macrophage T Cell and T Cell-B Cell Interaction
The Monogamous T Helper Cell
Human B-Cell Activation In Vitro: Antigen-Specific Helper and Suppressor Effects Are Mediated by Distinct T-Cell Subpopulations
Differentiation of Helper T Cells Operative in Antibody Synthesis and Cell-Mediated Lympholysis (CML)
Viruses and Alloantigens Can Act as Helper Determinants for Antibody Responses to Another Surface Antigen, THY-1
Workshop Report: Intercellular Cooperation
Section 3 Suppressor Cells
Immune Surveillance and Fetomaternal Relationships: Suppression of Immune Functions by Mouse Amniotic Fluid
Active Cell-Mediated Suppression for Histocompatibility Determinants Produced by T Cells from Normal or Tolerant Mice
Characterization of Suppressive T Cell Fc Receptor, Its Relation with the Major Histocompatibility Complex
Suppressor Cells Regulating the in Vivo Induction of Cytotoxic T Lymphocytes and of Memory Cells for a Secondary in Vitro CMC Response
Multiple Subpopulations of Lymphoid Cells Regulating Human B-Cell Function
Workshop Report: Suppressor Cells
Section 4 Soluble Immunoregulatory Molecules (Lymphokines)
In Vivo Release of Lymphokines
Immunological Role of Macrophage- and Lymphocyte-Derived Amplification Factors
Biochemical Characterization of MIF Maf Macrophage Interactions: A Putative Glycolipid Receptor for MIF, the Existence of Two Distinct MIFs, and Their
Regulation by Macrophage- Associated Esterases
Different Cellular Sources for the Production of Immunue Interferon and Macrophage Migration Inhibitory Factor
Biological Activities of a Macrophage Chemotaxis Inhibitor (MCI) Produced by Neoplasma
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