Dynamics of Degeneration and Growth in Neurons

Dynamics of Degeneration and Growth in Neurons is a collection of papers presented at the International Symposium on the Dynamics of Degeneration and Growth in Neurons, held in Stockholm, Sweden, on May 16-18, 1973. Contributors explore the dynamics of degeneration and growth of central and peripheral neurons, touching on a wide range of topics such as the neurotoxic action of 6-hydroxy-dopa on central catecholamine neurons; axonal transport of proteins in growing and regenerating neurons; and collateral reinnervation in the central nervous system.

Comprised of 50 chapters, this volume begins with an overview of degeneration processes in central and peripheral neurons. Results of microfluorimetric and neurochemical studies on degenerating and regenerating adrenergic nerves are presented. The next section is devoted to axoplasmic transport as a mechanism for axonal support and growth and includes chapters dealing with the effects of degeneration and axoplasmic transport blockade on synaptic ultrastructure, function, and protein composition; the role of axoplasmic flow in trophism of skeletal muscle; and proximodistal transport of acetylcholine in peripheral cholinergic neurons. The remaining chapters discuss the nerve growth factor receptor and its specific binding in sympathetic ganglia; the noradrenergic innervation of cerebellar Purkinje cells; and the possible role of brain and peripheral monoamines in the ontogenesis of normal and drug-induced responses in the immature mammal.

This book will be of interest to physiologists and neurologists.

Contenu

Chapter 1: OPENING ADDRESS

Session I: DEGENERATION PROCESSES IN PERIPHERAL AND CENTRAL NEURONS

Chapter 2: THE LIGHT AND ELECTRON MICROSCOPICAL APPEARANCE OF ANTEROGRADE AND RETROGRADE NEURONAL DEGENERATION

Chapter 3: THE DEGENERATION PATTERN OF THE NIGRO-NEOSTRIATAL DOPAMINE SYSTEM AFTER ELECTROTHERMIC OR 6-HYDROXY-DOPAMINE LESIONS

Chapter 4: STRUCTUREâEUR"ACTIVITY CORRELATIONS IN TRIHYDROXYPHENETHYLAMINES AND DIHYDROXYTRYPTAMINES RELATIONSHIP TO CYTOTOXICITY IN ADRENERGIC AND SEROTONERGIC NEURONS

Chapter 5: NEUROTOXIC ACTION OF 6-HYDROXY-DOPA ON CENTRAL CATECHOLAMINE NEURONS

Chapter 6: MICROFLUORIMETRIC AND NEUROCHEMICAL STUDIES ON DEGENERATING AND REGENERATING ADRENERGIC NERVES

Chapter 7: LATE AND EARLY BIOCHEMICAL CHANGES IN CENTRAL CATECHOLAMINE NEURONS AFTER AXOTOMY

Chapter 8: BIOCHEMICAL AND MORPHOLOGICAL CHANGES AFTER MECHANICAL OR CHEMICAL DEGENERATION OF THE DOPAMINERGIC NIGRO-NEOSTRIATAL PATHWAY

Chapter 9: CHANGES IN CATECHOLAMINE SYNTHESIZING ENZYME ACTIVITIES DURING NEURONAL GROWTH AND DEGENERATION

Chapter 10: SOME ASPECTS OF THE REACTION OF CENTRAL AND PERIPHERAL NORADRENERGIC NEURONS TO INJURY

Chapter 11: EFFECTS OF BRETYLIUM, RELATED QUATERNARY AMMONIUM COMPOUNDS, AND MITOSIS INHIBITORS ON THE DEGENERATION ACTIVITY IN THE SYMPATHETICALLY INNERVATED PERIORBITAL SMOOTH MUSCLE IN THE CONSCIOUS RAT

Chapter 12: NORADRENALINE NERVE TERMINALS IN THE RAT CEREBRAL CORTEX FOLLOWING LESION OF THE DORSAL NORADRENALINE PATHWAY: A STUDY ON THE TIME COURSE OF THEIR DISAPPEARANCE

Session II: DEGENERATION PROCESSES IN PERIPHERAL AND CENTRAL NEURONS

Chapter 13: STUDIES ON THE NEUROTOXIC PROPERTIES OF HYDROXYLATED TRYPTAMINES

Chapter 14: STUDIES ON CENTRAL 5-HYDROXYTRYPTAMINE NEURONS USING DIHYDROXYTRYPTAMINES: EVIDENCE FOR REGENERATION OF BULBOSPINAL 5-HYDROXYTRYPTAMINE AXONS AND TERMINALS

Chapter 15: EFFECTS OF DRUGS ON SYMPATHETIC NERVE CELLS AND SMALL INTENSELY FLUORESCENT (SIF) CELLS

Chapter 16: THE EFFECT OF INDUSTRIAL SOLVENTS ON ADRENERGIC TRANSMITTER MECHANISMS

Session I: AXOPLASMIC TRANSPORT AS A MECHANISM FOR AXONAL SUPPORT AND GROWTH

Chapter 17: DYNAMICS AND MECHANICS OF NEUROPLASMIC FLOW

Chapter 18: EFFECTS OF DEGENERATION AND AXOPLASMIC TRANSPORT BLOCKADE ON SYNAPTIC ULTRASTRUCTURE, FUNCTION, AND PROTEIN COMPOSITION

Chapter 19: AXONAL TRANSPORT OF PROTEINS IN GROWING AND REGENERATING NEURONS

Chapter 20: THE ROLE OF AXOPLASMIC FLOW IN TROPHISM OF SKELETAL MUSCLE

Session II: AXOPLASMIC TRANSPORT AS A MECHANISM FOR AXONAL SUPPORT AND GROWTH

Chapter 21: DIFFERENTIAL ACCUMULATION OF ENZYMES IN CONSTRICTED NERVES ACCORDING TO THEIR SUBCELLULAR LOCALIZATION

Chapter 22: IMPORTANCE OF AXOPLASMIC TRANSPORT FOR TRANSMITTER LEVELS IN NERVE TERMINALS

Chapter 23: INTRA-AXONAL TRANSPORT MECHANISMS IN THE NORADRENERGIC NEURON

Chapter 24: PROXIMODISTAL TRANSPORT OF ACETYLCHOLINE IN PERIPHERAL CHOLINERGIC NEURONS

Chapter 25: AXONAL TRANSPORT OF DOPAMINE-β-HYDROXYLASE BY ABNORMAL HUMAN SURAL NERVES

Session I: GROWTH

Chapter 26: CONTROL MECHANISMS OF THE ADRENERGIC NEURON

Chapter 27: REGULATION OF ENZYME SYNTHESIS BY NEURONAL ACTIVITY AND BY NERVE GROWTH FACTOR

Chapter 28: ASSAY OF NERVE GROWTH FACTOR (NGF) IN MOUSE TISSUE AND THE ROLE OF NGF AND DEPOLARIZING STIMULI IN THE LONG-TERM REGULATION OF TYROSINE HYDROXYLASE ACTIVITY IN ADRENERGIC NEURONS

Chapter 29: THE NERVE GROWTH FACTOR RECEPTOR: DEMONSTRATION OF SPECIFIC BINDING IN SYMPATHETIC GANGLIA

Chapter 30: DNA SYNTHESIS AND CELL DIVISION IN DIFFERENTIATING AVIAN ADRENERGIC NEUROBLASTS

Session II: GROWTH

Chapter 31: COLLATERAL REINNERVATION IN THE CENTRAL NERVOUS SYSTEM

Chapter 32: GROWTH OF ADRENERGIC NEURONS IN THE ADULT MAMMALIAN NERVOUS SYSTEM

Chapter 33: HAS NERVE GROWTH FACTOR A ROLE IN THE REGENERATION OF CENTRAL AND PERIPHERAL CATECHOLAMINE NEURONS?

Session III: GROWTH

Chapter 34: THE NORADRENERGIC INNERVATION OF CEREBELLAR PURKINJE CELLS: LOCALIZATION, FUNCTION, SYNAPTOGENESIS, AND AXONAL SPROUTING OF LOCUS COERULEUS

Chapter 35: BIOCHEMICAL ASPECTS OF THE CATECHOLAMINERGIC NEURONS IN THE BRAIN OF THE FETAL AND NEONATAL RAT

Chapter 36: ONTOGENESIS OF CENTRAL AND PERIPHERAL ADRENERGIC NEURONS IN THE RAT FOLLOWING NEONATAL TREATMENT WITH 6-HYDROXYDOPAMINE

Session IV: GROWTH

Chapter 37: AGGLUTININS OF FORMALINIZED ERYTHROCYTES: CHANGES IN ACTIVITY WITH DEVELOPMENT OF DICTYOSTELIUM DISCOIDEUM AND EMBRYONIC CHICK BRAIN

Chapter 38: GROWTH AND DEVELOPMENT OF CHOLINERGIC AND ADRENERGIC NEURONS IN A SYMPATHETIC GANGLION: RECIPROCAL REGULATION AT THE SYNAPSE

Chapter 39: HETEROGENOUS REINNERVATION OF SYMPATHETIC LUMBAR GANGLIA WITH SYMPATHETIC POSTGANGLIONIC NERVES

Chapter 40: ONTOGENESIS OF CENTRAL NORADRENALINE NEURONS AFTER 6-HYDROXYDOPAMINE TREATMENT AT BIRTH

Chapter 41: EFFECTS OF VINBLASTINE ON PERIPHERAL AUTONOMIC NERVES: DEGENERATION AND FORMATION OF NEW NERVE FIBERS

Chapter 42: NERVE GROWTH SPECIFICITY AND REGULATION AS REVEALED BY INTRAOCULAR BRAIN TISSUE TRANSPLANTS

Chapter 43: DEGENERATION AND ORIENTED GROWTH OF AUTONOMIC NERVES IN RELATION TO SMOOTH MUSCLE IN JOINT TISSUE CULTURES AND ANTERIOR EYE CHAMBER TRANSPLANTS

Chapter 44: ELECTROPHYSIOLOGICAL AND HISTOCHEMICAL PROPERTIES OF FETAL HUMAN SPINAL CORD IN TISSUE CULTURE

Session I: RECEPTOR CHANGES IN RELATION TO DEGENERATION AND DEVELOPMENT OF NEURONS AND DRUG TREATMENT

Chapter 45: AUTONOMIC NEURO-RECEPTOR MECHANISMS IN BRAIN VESSELS

Chapter 46: PHARMACOLOGICAL APPROACHES TO MONOAMINE RECEPTORS DURING BRAIN DEVELOPMENT

Chapter 47: BRAIN AND PERIPHERAL MONOAMINES: POSSIBLE ROLE IN THE ONTOGENESIS OF NORMAL AND DRUG-INDUCED RESPONSES IN THE IMMATURE MAMMAL

Chapter 48: ENHANCED ACCUMULATIONS OF CYCLIC AMP IN BRAIN SLICES ELICITED BY NOREPINEPHRINE AFTER INTRAVENTRICULAR PRETREATMENT OF RATS WITH 6-HYDROXYDOPAMINE

Chapter 49: ENHANCED SENSITIVITY TO THE NORADRENALINE RECEPTOR STIMULATING AGENT, CLONIDINE, FOLLOWING DEGENERATION OF NORADRENALINE PATHWAYS: STUDIES ON ARTERIAL PRESSURE, HEART RATE, AND RESPIRATION

Chapter 50: LEARNING DEFICITS IN OFFSPRING OF THE NURSING MOTHERS GIVEN PENFLURIDOL

Chapter 51: EFFECTS OF PRE- AND POSTNATAL INJECTION OF 6-HYDROXYDOPAMINE ON SLEEP AND BIOGENIC AMINES OF ADULT RAT