DNA Photodamage

Induction of DNA damage by sunlight is a major deleterious event in living organisms. Recent developments have dramatically improved our understanding of the photochemical processes involved at the sub-picosecond time scale and along with next generation sequencing and data processing has generated a need for a complete up-to-date coverage of the field. Written in an accessible and comprehensive manner, DNA Photodamage will appeal to all scientists working in the area whether specialists in the discipline or not and provides a complete coverage of the field, from ultrafast spectroscopy to biomedical research. Bridging the gap between photophysical and photochemical research on model systems, and in vivo and in vitro biological studies, this book aims to identify the most important research trends in the field and review their major findings.

Contenu

Photoinduced Processes in DNA: Basic Theoretical and Experimental Features; Photoinduced Dimerization in DNA: Singlet Excited State Reaction Paths; DNA Photoionization: From High to Low Energies; Triplet Channel Photochemistry in DNA; Tracking Excited Electronic States in DNA From Formation to Deactivation; Influence of DNA Structure on Lesion Formation and Repair: Role of Modelling and Simulations; Ultraviolet-induced Formation of DNA Damage in Cells and their Mutational Consequences; Deamination of C-containing Cyclobutane Pyrimidine Dimers and Its Role in C to T and CC to TT Signature Mutations Caused by UV Light; Photochemistry of RNA, RNA Monomers, and Plausible Prebiotic Precursors; Photodamage in Mitochondria; Repair of UV-induced DNA Damage and RNA: A Helpful Interplay for Genome Surveillance; How do Translesion Polymerases Deal With Photodamage?