Stereochemistry and Organic Reactions

Stereochemistry and Organic Reactions: Conformation, Configuration, Stereoelectronic Effects and Asymmetric Synthesis provides coverage on the stereochemistry of reactions of all mechanistic types, ranging from ionic, pericyclic and transition metal-catalyzed to radical and photochemical. Chapters cover acyclic molecules, cyclic molecules, the stereochemistry of organic reactions, the perturbation molecular orbital theory for the origin of stereoelectronic effects, and an introduction to the principles of stereoselectivity and hierarchical levels of asymmetric synthesis. Each chapter includes problems that reinforce main themes, making it valuable to students, teachers and researchers working in organic, biological and medicinal chemistry, as well as biologists, pharmacologists, polymer chemists and chemists.

• Presents a holistic and unified approach to stereochemical understanding and predictions, covering reactions of all mechanistic classes
• Includes two background chapters on perturbation theory and stereoselective principles, along with asymmetric designs
• Features novel rules and mnemonics to delineate product stereochemistry
• Includes up-to-date coverage with over 1300 selective references

Auteur

Dipak K. Mandal is former professor of chemistry at Presidency College (University), Kolkata, India. He studied chemistry at Presidency College and Calcutta University, and is a recipient of university gold medal and Bhubana Mohini gold medal. He completed his PhD thesis under the supervision of Professor N. K. Sinha at Bose Institute, Kolkata and carried out postdoctoral work in the USA from 1990-1993 with Professor C. Fred Brewer at Albert Einstein College of Medicine, New York. He has been passionately involved in teaching undergraduate and graduate level organic chemistry for about 35 years, and his keen interest in chemical education resulted in three publications in the Journal of Chemical Education. His research interests include protein folding, structure and dynamics, and peptide synthesis. He was actively engaged in guiding research and has published many research papers in peer-reviewed international journals.

Contenu

Part I: Stereochemistry of Organic Molecules 1. Acyclic Molecules 1: Conformation and Symmetry 2. Acyclic Molecules 2: Configuration and Resolution 3. Cyclic Molecules: Configuration and Conformation

Part II: Introduction to Stereoelectronic Effects and Stereoselective Principles 4. Perturbation Theory and Organic Reactions 5. Introduction to Stereospecificity, Stereoselectivity and Asymmetric Synthesis

Part III: Stereochemistry of Organic Reactions 6. Ionic Reactions 1: Fundamental Stereochemistry 7. Ionic Reactions 2: Diastereoselectivity and Asymmetric Synthesis 8. Pericyclic Reactions 1: Basic Stereochemistry 9. Pericyclic Reactions 2: Asymmetric Synthesis 10. Transition Metal-Catalyzed Reactions: Diastereoselectivity and Asymmetric Synthesis 11. Radical Reactions: Stereochemistry and Asymmetric Synthesis 12. Photochemical Reactions: Stereochemistry and Asymmetric Synthesis