Developmental Aspects of the Cell Cycle

Developmental Aspects of the Cell Cycle discusses the molecular, organelle, cellular, and organismal levels of cell cycle, cell proliferation, and cell differentiation. It addresses the possible antagonism between the ability of cells to proliferate and to differentiate.
After brief historical, theoretical, and methodological background information for each cell system, this book concentrates on the mechanisms involved in the regulation of cell proliferation and differentiation. The book presents systems in which mass cultures of cells can be induced to undergo a synchronous transition from one cell state to another, enabling the amplification of cellular and biochemical events to be analyzed with the available morphological and biochemical techniques. Some chapters explain the possibility of cell state production by a microenvironment that occurs at the organismal level, in which a series of mitotic and growth steps causes cells proliferation. The concluding chapters discuss cell proliferation and differentiation in specific cell system, such as embryonic chick and male germ cell.
This book will appeal to investigators in many disciplines, teachers, and life sciences students, particularly, to molecular, cellular, and developmental biologists.

Contenu

List of Contributors
Preface

1. The Cell Cycle and Cell Differentiation in Trypanosomatids
   I. Introduction
   II. Life Cycles and Cell Differentiation
   III. Cell Cycles and Differentiation
   References
2. Characteristics of Macronuclear RNA in the Cell Cycle of Synchronized Tetrahymena
   I. Introduction
   II. Nucleocytoplasmic Interactions
   III. Stomatogenesis and Polyribosomal Assembly
   IV. Nucleic Acid Synthesis
   V. Summary and Concluding Remarks
   References
3. Cell Transformation Studies on the Amoeba-Flagellate, Naegleria gruberi
   I. Introduction
   II. Historical Aspects
   III. Modern Studies
   IV. Concluding Remarks
   References
4. Temporal Patterns in the Ciliated Protozoa
   I. The Nature of Temporal Events
   II. Maturity Patterns in Tetrahymena
   III. Mechanisms of Temporal Control
   IV. Concluding Remarks
   References
5. Mitosis and Differentiation in Hydra Morphogenesis
   I. Introduction
   II. Structural Aspects
   III. Selection of Experimental Hydra
   IV. Techniques for Analyzing Mitosis in Hydra
   V. Effects of Mitotic Inhibitors on Regeneration and Morphogenesis
   VI. Concluding Remarks
   References
6. Radiation Responses during the Mitotic Cycle of the Sea Urchin Egg
   I. Introduction
   II. General Effects of Irradiating Gametes or Zygotes
   III. Effects on Sperm
   IV. Effects on Unfertilized Eggs
   V. Cyclical Changes
   VI. Questions Concerning Targets
   VII. General Conclusions and Considerations for the Future
   References
7. Cell Division and Transcription in Developing Frog Embryos
   I. Relation of Cell Division to Differentiation
   II. RNA Synthesis in Developing Frog Embryos
   III. Relation of Transcription to Time of DNA Replication
   IV. Effect of Rate and Number of Divisions on Transcription
   V. Summary
   References
8. Relationship between Cell Proliferation and Cytodifferentiation in Embryonic Chick Tissues
   I. Introduction
   II. Review of Individual Developing Systems
   III. Discussions and Conclusions
   References
9. Studies on Cellular Proliferation and Chondrogenesis
   I. Introduction
   II. Cell Cycle and Chondrogenesis
   III. Discussion
   IV. Summary
   References
10. Differentiation of the Male Germ Cell
    I. Introduction
    II. The Cycle of the Seminiferous Epithelium
    III. Gametogenesis
    IV. Final Stages of Spermatozoan Differentiation-The Female Reproductive Tract
    References
11. Immunoglobulin Production in Proliferating Lymphoid Cells
    I. Introduction
    II. Immunoglobulin Synthesis in Relation to Culture Dynamics
    III. Immunoglobulin Gene Expression during the Cell Cycle
    IV. Discussion
    V. Summary
    References
12. Initial Stages of Cellular Differentiation in the Blood-Forming System of the Mouse
    I. Introduction
    II. Cellular Organization in the Hemopoietic System
    III. Regulation of Stem Cell Functions
    IV. Summary
    References
13. Hormonal Regulation of Cell Proliferation and Differentiation
    I. Introduction
    II. Hormonal Regulation of Cell Proliferation
    III. Hormone-Dependent Cell Differentiation
    IV. Relationship of Proliferation to Differentiation
    V. Some Possible Mechanisms in Hormonal Regulation of Gene Expression
    VI. Summary
    References
    Author Index
    Subject Index