Design and Applications of Nanoparticles in Biomedical Imaging

This book covers the most recent advances in using nanoparticles for biomedical imaging, including magnetic resonance imaging (MRI), magnetic particle imaging (MPI), nuclear medicine, ultrasound (US) imaging, computed tomography (CT), and optical imaging. Topics include nanoparticles for MRI and MPI, siRNA delivery, theranostic nanoparticles for PET imaging of drug delivery, US nanoparticles for imaging drug delivery, inorganic nanoparticles for targeted CT imaging, and quantum dots for optical imaging. This book serves as a valuable resource for the fundamental science of diagnostic nanoparticles and their interactions with biological targets, providing a practical handbook for improved detection of disease and its clinical implementation.

Auteur
Jeff W.M. Bulte is affiliated with The Johns Hopkins University School of Medicine, Russell H. Morgan Department of Radiology and Radiological Science, Baltimore, MD, USA.
Michel M.J. Modo is affiliated with the University of Pittsburgh, Department of Radiology, Pittsburgh, PA, USA.

Contenu

Preface.- 1. Introduction.- 2. Basic principles of in vivo distribution, toxicity, degradation of prospective inorganic nanoparticles for imaging.- 3. Imaging and therapeutic potential of extracellular vesicles.- 4. Magnetic Particle Imaging.- 5. Multispectral MR Imaging and Sensing Using Shaped Nanoparticles.- 6. Magnet-targeted delivery and imaging.- 7. Spinning to a different beat: 19F agents for hot spot cellular MR imaging.- 8. Nanoformulations for Pharmacological siRNA Delivery in Cancer.- 9. Forming Magnetosome-like Nanoparticles in Mammalian Cells for Molecular MRI.- 10. PET/SPECT/MRI multimodal nanoparticles.- 11. Nanoparticles for PET Imaging of Tumors and Cancer Metastasis.- 12. Theranostic Nanoplatforms for PET Image-Guided Drug Delivery.- 13. Triggered drug release and enhanced drug transport from ultrasound-responsive nanoparticles.- 14. Nanoparticles for ultrasound-guided imaging of cell implantation.- 15. Photoacoustic Imaging of Cancer Using Nanoparticles.- 16. Photoacoustic Imaging of Vasculature.- 17. Nanoparticles for Cardiovascular Imaging with CT.- 18. Molecular Imaging with Spectral CT Nanoprobes.- 19. Theranostic gold nanoparticles for CT imaging.- 20. Bismuth-Based Nanoparticles for CT Imaging.- 21. Hyperspectral microscopy and cellular array imaging using colloidal quantum dots.- Index.