Dental Enamel

The molecular mechanisms and protein species associated with the mineralization of mature dental enamel are active areas of research. This book focuses on specific areas of research including the structural chemistry, protein biochemistry and genetics of enamel development.

Auteur

Derek J. Chadwick and Gail Cardew are editors for Dental Enamel and other scientific titles.

Texte du rabat
The molecular mechanisms and protein species involved in enamel development and mineralization are areas of active research and debate. There is much to learn about the roles of the enamel matrix proteins (e.g. amelogenins and enamelins/tuftelins and ameloblastins) secreted by ameloblasts, as well as the process of abnormal enamel development, which may result either from inherited genetic defects (amelogenesis imperfecta) or from systemic or environmental factors such as fluoride. The aim of this book is to evaluate many of the recent advances in this field: the genetics and structural biology of the enamel matrix proteins; the structure/function relationships of these proteins in normal and diseased enamel; the new cellular, molecular, evolutionary and computational approaches that are fuelling progress towards the understanding of enamel genesis; and the biomimetic or tissue engineering approaches that may result in improved diagnostics and therapeutics. It contains lively debates from an international group of experts who have identified future directions both for the ?science? of dental enamel and health-related opportunities.

Contenu
Partial table of contents: Tooth Morphogenesis and the Differentiation of Ameloblasts (I. Thesleff, T. Åberg).

Microstructure of Enamel (A. Boyde).

Structure, Crystal Chemistry and Density of Enamel Apatites (J. Elliott).

Inherited Enamel Defects (B. Bäckman).

Molecular Biology of Hereditary Enamel Defects (M. Aldred P. Crawford).

Determinants and Mechanisms of Enamel Fluorosis (G. Whitford).

Indexes.