Lymphocyte Differentiation, Recognition, and Regulation provides an overview of the state of knowledge on cellular immunology. The focus is on animal work than on studies in man, although in certain areas human lymphocyte biology has been discussed in some detail. The book attempts to integrate information from diverse areas of cellular immunology, immunogenetics, and immunochemistry to form some cohesive concepts that can be perhaps utilized as a working foundation for students and investigators in various areas of immunology.
The book begins with a general description of some of techniques and principles underlying the systems frequently employed in cellular immunology. This is followed by detailed analyses of lymphocyte differentiation, receptor function, and regulatory processes. The main points that emerge from such analyses are that the immune system is an infinitely complex and finely tuned network of cells, receptors, and molecules which interact with one another in a genetically controlled manner that is manifested ultimately in the process known as differentiation.

Contenu

Preface
I Introduction
The Two Major Classes of Immunocompetent Lymphocytes
II Surface Antigens and Markers on T Lymphocytes
A. Antigens Found Exclusively on T Cells
B. Antigens on T Lymphocytes and on Other Nonlymphoid Cells, but Not Present on B Lymphocytes
III Surface Antigens and Markers on B Lymphocytes
A. Antigens Found Exclusively on Cells of the B Lymphocyte Lineage
B. Antigens on B Lymphocytes and on Other Nonlymphoid Cells, but Not Present on T Lymphocytes
IV Surface Antigens Present on L Lymphocytes and also on B Lymphocytes
A. The Major Histocompatibility Antigens
B. The I-Region-Associated (Ia) Antigens
C. The Fc Receptor (FcR)
D. The Thymus-B Cell Common Antigen (Th-B)
E. The LY-8 Antigen
V Ontogeny of the Two Major Classes of Lymphocytes
A. General Considerations
B. Ontogeny of T Lymphocytes
C. Ontogeny of B Lymphocytes
VI Surface Immunoglobulin on Lymphocytes
A. Introduction
B. Detection of Surface Immunoglobulin
C. Quantitation of Surface Ig
D. Tissue Distribution of Surface Ig+ Lymphocytes
E. Ontogeny of Ig+ Lymphocytes
F. Immunoglobulin Class Expression of Surface Ig on Lymphocytes
G. Movement and Redistribution of Surface Immunoglobulin Molecules on B Lymphocytes
H. Surface Immunoglobulin on T Lymphocytes
I. Properties of Surface Immunoglobulin Isolated from B Lymphocytes
VII Immunological Specificity of Immunocompetent Lymphocytes
A. Functional Evidence for Specificity in T and B Lymphocytes
B. Comparative Specificities of the T and B Cell Repertoires
C. Determinant Specificity of T and B Cell Receptors
D. Antigen Receptors on B Lymphocytes
E. Antigen Receptors on T Lymphocytes
VIII Functional Properties of T Lymphocytes
A. Regulatory T Lymphocytes
B. Effector T Lymphocytes
C. Differential Sensitivities of T Cell Subpopulations to Chemical and Physical Manipulations
IX Functional Properties of B Lymphocytes
A. Antibody-Forming Cell Precursors (AFCP)
B. Functional Subpopulations of B Lymphocytes Distinguished by Relative Dependence on T Cells
C. Other Criteria for Functional Subpopulations of B Lymphocytes
D. Genetic Defects in T Lymphocyte Function
X Regulatory Cellular Interactions in Immune Responses
A. Basic Models of T-B Cell Interactions
B. Nature of the Regulatory Influence of Activated T Cells on Antibody Production
C. Suppressive Effects of T Lymphocytes on Antibody Production
D. T Cell Regulation of IgE Antibody Synthesis
E. Basic Models of T-T Cell Interactions
F. Suppressive Effects of T Cells on Cell-Mediated Immune Responses
XI The Allogeneic Effect on Immune Responses
A. Essential Features of the Allogeneic Effect on Antibody Responses
B. Mediation of the Allogeneic Effect via Development of the Graft-versus-Host Reaction
C. The Allogeneic Effect In Vitro
D. Relevance of the Allogeneic Effect to the Mechanism of Regulatory Physiological Interactions between T and B Lymphocytes in Immune Responses
E. Pathophysiological Significance of the Allogeneic Effect
F. Conclusions
XII Genetic Control of Immune Responses and Cellular Interactions
A. Histocompatibility-Linked Ir Genes
B. Histocompatibility-Linked Immune Suppression (Is) Genes
C. The Role of Products of the Major Histocompatibility Complex in Cellular Interactions Which Regulate Immune Responses
D. Relationship of Histocompatibility Gene Products to Each Other in Nature and Function
E. General Conclusions
XIII Mechanisms of Regulatory Cellular Interactions
A. General Considerations
B. Properties of Biologically Active Products of Activated T Cells and Macrophages Mediating Helper or Suppressor Activities
C. Hypothetical Models for Cellular Interactions
XIV Immunological Tolerance
A. Historical Perspective
B. Target Cells for Tolerance Induction
C. Mechanisms of Tolerance Induction in Either T or B Lymphocytes
D. Interrelationships among the Alternative Pathways to Unresponsiveness
E. Relationships of the Alternative Pathways to Induction and Maintenance of Self-Tolerance
F. Concluding Remarks
XV Concluding Remarks
Glossary
Bibliography
Index