Cognitive Neuroscience of Aging

This second edition of the popular Cognitive Neuroscience of Aging provides up-to-date coverage of the most fundamental topics in this discipline. Like the first edition, this volume accessibly and comprehensively reviews the neural mechanisms of cognitive aging appropriate to both professionals and students in a variety of domains, including psychology, neuroscience, neuropsychology, neurology, and psychiatry. The chapters are organized into three sections. The first section focuses on major questions regarding methodological approaches and experimental design. It includes chapters on structural imaging (MRI, DTI), functional imaging (fMRI), and molecular imaging (dopamine PET, etc), and covers multimodal imaging, longitudinal studies, and the interpretation of imaging findings. The second section concentrates on specific cognitive abilities, including attention and inhibitory control, executive functions, memory, and emotion. The third section turns to domains with health and clinical implications, such as the emergence of cognitive deficits in middle age, the role of genetics, the effects of modulatory variables (hypertension, exercise, cognitive engagement), and the distinction between healthy aging and the effects of dementia and depression. Taken together, the chapters in this volume, written by many of the most eminent scientists as well as young stars in this discipline, provide a unified and comprehensive overview of cognitive neuroscience of aging.

Auteur

Roberto Cabeza is Professor of Psychology and Neuroscience at Duke University, where he is also Director of the Center for Cognitive Neuroscience. Cabeza investigates the neural mechanisms of memory in young and older adults using behavioral, functional neuroimaging, and brain stimulation techniques. Lars Nyberg is professor at Umeå University, Sweden (in Psychology until 2005, and in Neuroscience since 2006) and director of Umeå Center for Functional Brain Imaging. He is a principal investigator of the Betula longitudinal project. Denise C. Park is Distinguished University Chair of Behavioral and Brain Science at the University of Texas at Dallas. She has held numerous offices in national professional organizations and is a fellow of AAAS, American Psychological Association, American Psychological Society, and Gerontological Society of America. Park has received the Distinguished Scientific Contribution Award (2002) and the Distinguished Mentor Award (2015) from the Division of Adult Development and Aging of the American Psychological Association. She has studied the aging mind her entire career and is presently focused on techniques for enhancing cognitive function through neuroplasticity and understanding the transition from cognitive health to Alzheimer's disease.

Contenu

Contributors Introduction I. Methods and Issues 1. MRI measures of aging: methodological issues Hanzhang Lu & Peiying Liu 2. Molecular imaging of aging and neurodegenerative disease Anna Rieckmann, Randy L. Buckner & Trey Hedden 3. Age differences in structural connectivity: DTI and WMHs David J. Madden & Emily L. Parks 4. Age differences in functional connectivity at rest and during cognitive tasks Cheryl L. Grady 5. Multi-modal imaging of the aging brain Anders M. Fjell & Kristine B. Walhovd 6. Structural and functional imaging of aging: longitudinal studies Lars Nyberg, Sara Pudas, & Anders Lundquist 7. Interpreting age-related differences in memory-related neural activity Michael D. Rugg II. Cognitive Processes 8. Selective attention and inhibitory control in the aging brain Theodore P. Zanto & Adam Gazzaley 9. Working memory and executive functions in the aging brain Patricia A. Reuter-Lorenz & Cindy Lustig 10. Neural correlates of age-related slowing Timothy A. Salthouse 11. The aging hippocampus: linking animal and human research Shauna M. Stark & Craig E. L. Stark 12. Episodic memory encoding and retrieval in the aging brain Wei-Chun Wang & Roberto Cabeza 13. Emotion and emotional memory Elizabeth A. Kensinger & Jaclyn H. Ford III. Health and disease 14. The middle-aged brain: A cognitive neuroscience perspective Denise C. Park & Sara B. Festini 15. The modifying role of hypertension in cognitive and brain aging Karen M. Rodrigue & Gerard N. Bischof 16. Genetics and cognitive neuroscience of aging Goren Papenberg, Ulman Lindenberger & Lars Backman 17. Effects of exercise on cognition, brain structure, and brain function in older adults Kirk I. Erickson & Lauren E. Oberlin 18. The link of intellectual engagement to cognitive and brain aging. Martin Lövdén, Lars Backman & Ulman Lindenberger 19. Disambiguating preclinical Alzheimer's disease from cognitive aging Reisa Sperling 20. Late-Life Depression: Translating Neurobiological Hypotheses into novel treatments. George S. Alexopoulos & Robert E. Kelly Index