Chronic Myeloid Leukemia

This book provides state-of-the-art reviews of key issues and recent developments relating to chronic myeloid leukemia (CML), acquainting the reader with advances in research, treatment, and promotion of public health. Among the management topics addressed are the choices, advantages, and pitfalls of first-, second-, and third-line treatments; the European LeukemiaNet recommendations; management of adverse effects of tyrosine kinase inhibitors (TKI); management of CML blast crisis; management of pregnancy in the context of CML; the role of hematopoietic cell transplantation; the current experience with TKI discontinuation; and the value of interferon a in improving the outcome of TKI treatment. Various aspects of relevance to treatment outcome are discussed, including prognostic scores, molecular monitoring (principles and interlaboratory standardization), and response-related predictors of survival. Furthermore, updates are provided on the increasing prevalence of CML and its implications and on the changing cost of care for CML, taking into account the forthcoming impact of availability of generic imatinib.

Auteur

Rüdiger Hehlmann is a Professor of Medicine at the Mannheim Medical Faculty of the University of Heidelberg, Germany. Professor Hehlmann is past Chief of Medicine at Mannheim, past President of the German Society of Hematology and Oncology, past Dean of his faculty, and past Secretary General of the International Association of Comparative Research on Leukemia and Related Diseases (IACRLRD). He is founder and chair of the German CML Study Group, of the German Competence Network on acute and chronic leukemias, and of the European LeukemiaNet. He is an honorary member of the Polish and German Societies for Hematology and honorary doctor of the University of Uppsala, Sweden. He has received various awards for leukemia research and interdisciplinary cooperation. His research interests focus on leukemia, in particular CML, on mechanisms of leukemogenesis, and on progression to blast crisis.

Contenu
Cytogenetics of CML.- The biology and pathogenesis of CML.- The choice of 1st line CMLtreatment.- A review and update of the European LeukemiaNet recommendations for the management of CML.- Management of adverse events associated with ATPcompetitive BCRABL 1 tyrosine kinase inhibitors in CML.- Standardization of molecular monitoring for CML.- Epidemiology of CML.- Prognostic scores for patients with CML under particular consideration of disease specific death.- Responserelated predictors of survival.- CML blast crisis: implications and management.- Chronic Myeloid Leukemia and Pregnancy.- The role of hematopoietic stem cell transplantation in CML.- Discontinuation or cessation of tyrosine kinase inhibitor treatment in CML patients with deep molecular response.- The interferonalpha revival in CML.- Changing the cost of care for CML: the availability of generic imatinib.