Channelopathies in Heart Disease

This book provides an expert overview on ion channel-related arrhythmia mechanisms, and describes important advances in our understanding of how ion channel dysfunction causes cardiac disease. Both, scientific findings and clinical implications are presented and discussed by scientists who have considerably contributed to the field.

The book is organized in three parts: part I treats the molecular and electrophysiological mechanisms of function and dysfunction of ion channels, part II focuses on genetics and clinical findings, whereas part III describes novel research techniques, the use of stem cells and animal models and provides an outlook on future investigations and applications.

The book is written for scientists in Cardiovascular Biology and Neuroscience and will be of general interest to Medical Doctors in Cardiology, Cardiac Electrophysiology and related disciplines.

Auteur

Prof. Dr. med. Dierk Thomas is Associate Professor at the University of Heidelberg and Head of the Cardiac Electrophysiology Department, Medical University Hospital, University of Heidelberg, Germany.

Dr. Carol Ann Remme is Associate Professor and Principal Investigator at the Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands.

Contenu

Part A: (Dys)function of cardiac ion channels

2. The electrophysiological basis of cardiac conduction and repolarization (include also: Distribution of ion channels in the heart (atrium vs ventricle, conduction system versus working myocardium, Purkinje, transmural distribution))

Jules Hancox (University of Bristol, UK; Jules.Hancox@bristol.ac.uk)

3. Novel insights into ion channel complexity and diversity: relevance for cardiac channelopathies (interacting proteins, subcellular distribution, non-electrogenic effects, electro-mechanical overlap, impact on other organs, etc).

Hugues Abriel (Bern, CH)

4. Cardiac sodium channel structure and (dys)function

C.A. Remme (Amsterdam, NL)

5. Potassium channels in the heart: structure and (dys)function

Nicole Schmitt (Copenhagen, Denmark; nschmitt@sund.ku.dk)

6. Calcium channels and their roles in cardiac electrophysiology

Niels Voigt (Göttingen; Germany; niels-voigt@t-online.de)

7. HCN channels and cardiac pacemaking

Mirko Baruscotti (Department of Biomolecular Sciences and Biotechnology, University of Milan, Italy; mirko.baruscotti@unimi.it)

8. (Dys)regulation of ionic homeostasis: relevance for cardiac arrhythmias (including ryanodine receptor channelopathies, etc)

Luigi Venetucci (Institute of Cardiovascular Sciences, University of Manchester, UK; luigi.venetucci@manchester.ac.uk)

Part B: Cardiac channelopathies: clinical and genetic findings

9. Long QT syndrome (including Timothy syndrome), short QT syndrome &nb...