Central Adrenaline Neurons

Central Adrenaline Neurons: Basic Aspects and their Role in Cardiovascular Functions contains the proceedings of an international symposium held at The Wenner-Oren Center, Stockholm on August 27-28, 1979. The purpose of the meeting is to summarize the knowledge of central adrenaline neurons and their role in cardiovascular functions.
Organized into four sections, this book begins with a discussion on the morphology, biochemistry, and pharmacology of central adrenaline neurons. Subsequent sections detail the cardiovascular functions of central catecholamine neurons and the effects of centrally acting drugs on sympathetic function in normotensive and hypertensive patients. An overview lecture of the concept of a- and ß-adrenergic receptors is also shown.

Contenu

List of Participants

Preface

Opening Address

Section I The Morphology and Biochemistry of Central Adrenaline Neurons

The Anatomy of Central Cardiovascular Neurons

Histochemical Identification of Adrenaline Containing Cells with Special Reference to Neurons

Distribution and Characterization of PNMT and Epinephrine in the CNS

Section II The Pharmacology of Central Adrenaline Neurons

The Use of Liquid Chromatography with Electrochemical Detection for the Determination of Adrenaline and Other Biogenic Monoamines in the CNS

The Discovery of Potent Inhibitors of Phenylethanolamine N-Nethyltransferase (PNMT)

Pharmacologic Modification of Adrenaline Neurons in Rat Brain

Effect of DBH- and PNMT-Inhibition on Brain Adrenaline and Noradrenaline in Animals Exposed to Stress

Putative Regulation of Brain Norepinephrine Neurons by Epinephrine: Electrophysiological Studies

Section III Cardiovascular Functions of Central Catecholamine Neurons

Central Control of the Sympathetic Nervous System in Experimental Hypertension

Cardiovascular Effects of Piperoxan: A Putative Adrenaline Receptor Blocker

a -Adrenoreceptors and the Action of Clinidine-like Drugs

Catecholamines of the Nucleus tractus Solitarii and Blood Pressure Regulation

On the Role of Central Adrenaline Neurons in Central Cardiovascular Regulation

Effects of Antihypertensives and Other Drugs on Central Adrenaline Utilization

Adrenergic Receptor Mechanisms in the Central Nervous System in Relation to Catecholamine Neurons

Catecholamine-Stimulated Cyclic AMP Formation in Brainstem Nuclei of Normal Rats and Rats with Genetic Hypertension

The Hypotensive Actions of Centrally Administered Adrenaline

Brain Stem Adrenergic Neurons Participate in the Regulation of the Stress Response and in Genetic and Experimental Hypertension

Changes in Hypothalamic Adrenaline during Hyper- and Hypotensive States

The Role of Central Catecholamine Pathways in Spontaneous and Renal Hypertension in Rats

Central Effect of Adrenergic Compounds on Cat Respiratory Mechanisms

Overview Lecture

Radioligand Binding Studies of Adrenergic Receptors

Section IV Effects of Centrally Acting Drugs on Sympathetic Function in Normotensive and Hypertensive Patients

Elevated Plasma Adrenaline, Age-Related Decrease in Beta-Adrenoceptor-Mediated Cardiovascular Functions and Increase in Alpha-Receptor-Mediated Vasoconstriction in Essential Hypertension

The Contribution of Central and Peripheral Adrenoceptors to the Actions of Clonidine and Alpha Methyldopa in Man

Effect of Clonidine, Metoprolol and Penbutolol on Plasma Catecholamines and Renin Activity in Response to Sympathetic Stimulation in Hypertensive Patients

Subject Index