Cellular Basis of Chemical Messengers in the Digestive System

Cellular Basis of Chemical Messengers in the Digestive System contains the proceedings of an international symposium on the cellular basis of chemical messengers of the digestive system held in Santa Monica, California, on January 16, 17, and 18, 1980. The papers explore the entire spectrum of problems related to the cellular aspects of chemical messengers in the digestive system, with emphasis on which amines and peptides serve these functions and in which neurons and endocrine-paracrine cells each kind of chemical messenger is found.
This book is comprised of 28 chapters divided into six sections and begins by considering the nature of gut peptides and their possible functions. The discussion then turns to the diffuse neuroendocrine system and the phylogeny of the gastroenteropancreatic neuroendocrine system. Methods such as immunocytochemistry, electron immunohistochemistry, and electron microscopy autoradiography are then described. The following chapters focus on the function and morphology of endocrine-paracrine cells; immunochemical characterization of peptides in endocrine cells and nerves; Langerhans islets as the neuro-paraneuronal control center of the exocrine pancreas; and regulation of metabolism by gastroenteropancreatic peptides. The final section presents experimental results, including in vitro studies of canine pseudo-islets and of the mechanism of gastrin release.
This monograph will be of interest to physiologists and other practitioners in the field of medicine.

Contenu

List of Contributors and Participants
Preface
Other Titles in the Series
Introductory Topics
Nature of Gut Peptides and Their Possible Functions
The Diffuse Neuroendocrine System: Falsification and Verification of a Concept
Phylogeny of the Gastroenteropancreatic Neuroendocrine System: A Review
Membrane Recycling in Secretory Cells: Existence of Multiple Pathways Involving Golgi Cisternae, Secretory Granules, and Lysosomes
Methods
Use of EM Autoradiography and Organ Culture to Identify Pathways of Amine Synthesis in Human and Murine Gastric Endocrine Cells
Immunocytochemistry of Secretory Peptides: Introduction of a New Immunocytochemical Technique
Electron Immunohistochemistry of Gut Peptides in Tissues Processed for Routine Electron Microscopy
Immunocytochemical Investigations of the Gastroenteropancreatic Endocrine Cells Using Semithin and Thin Serial Sections
Structural and Functional Classification: Endocrine-Paracrine Cells
Function and Morphology in Gastric Endocrine Cells
Heterogeneity of the D1 Cell
Ultrastructural Identification of TG Cells in Man and Monkey
Neurotensin in the Central Nervous System, Gastrointestinal Tract, and Plasma: Its Isolation and Chemical Characterization
Multiple Secretory Messengers in Endocrine Cells and Neurons: ACTH-Related and Opioid Peptides in Gut and Brain
Human Gastroenteropancreatic Endocrine-Paracrine Cells: Santa Monica 1980 Classification
Structural and Functional Classification: Nerves
P-Type Nerves: Purinergic or Peptidergic
Polarity and Projections of Peptide-Containing Neurons in the Guinea Pig Small Intestine
Immunochemical Characterization of Peptides in Endocrine Cells and Nerves with Particular Reference to Gastrin and Cholecystokinin
Langerhans Islets as the Neuro-Paraneuronal Control Center of the Exocrine Pancreas
Classification of Gastroenteropancreatic Nerves
Pathological Aspects
Regulation of Metabolism by Gastroenteropancreatic Peptides
Evidence for Neurohormonal Peptides in Ovarian Carcinoids: A Preliminary Report of Immunohistochemical Findings
Distribution, Origin, and Pathology of the Gut Peptidergic Innervation
Experimental Aspects
Storage and Release of Serotonin and Serotonin-Binding Protein by Serotonergic Neurons
Distribution and Release of Peptides from Peripheral Neurons
Experimentally Induced Endocrine Pancreatic Tumors in the Rat
In Vitro Studies of Canine Pseudo-Islets
In Vitro Gastrin Release by Rat Antrum: Effects of Exogenous Prostaglandins
In Vitro Studies of the Mechanism of Gastrin Release: Comparison of the Results between Isolated G-Cell and Organ Culture Preparations
Author Index
Subject Index