Cellular and Molecular Renewal in the Mammalian Body

Cellular and Molecular Renewal in the Mammalian Body concerns the dynamic nature of body constituents at the molecular, organelle, and cellular level of structural organization.
Each chapter of this book deals with cellular and molecular renewal, proliferation, and loss, focusing on the body's major macromolecular classes, such as DNA, RNA, proteins, lipids, and carbohydrates.
Other topics discussed include the subcellular renewal, DNA stability, regulation of cell proliferation, and changes in mitotic rates. The intracellular sites of RNA synthesis, proteins of the nucleus, and epithelial-mesenchymal interactions are also elaborated. This text likewise covers the brown adipose tissue, histochemistry of polysaccharides, and calcification.
This publication is beneficial to students and investigators intending to acquire knowledge of the dynamic nature of body constituents and its influence to the analysis and experimentation of normal, disease, and repair processes within the body.

Contenu

List of Contributors
Preface

1. Approaches to the Study of Molecular and Cellular Renewal
   I. Introduction
   II. Cell Populations and Renewal
   III. Subcellular Renewal
   References
2. The Metabolic Stability of Nuclear DNA
   I. Introduction
   II. DNA Constancy
   III. DNA Stability
   IV. Conclusions
   References
3. Cell Proliferation and Renewal in the Mammalian Body
   I. Introduction
   II. Cell Proliferation and Growth during the Embryonic and Postnatal Periods
   III. Methods Used to Visualize and to Measure Cell Proliferation and Cell Renewal
   IV. Classification of Cell Populations Based on Their Proliferative Behavior
   V. Regulation of Cell Proliferation
   References
4. Cellular Content and Cellular Proliferation Changes in the Tissues and Organs of the Aging Mammal
   I. Introduction
   II. Changes in Numbers of Cells and Nerve Fibers
   III. Changes in Mitotic Rates
   IV. Changes in Mucosal Cells of the Intestine
   V. Discussion
   References
5. RNA Molecules in Cells and Tissues, In Vivo and In Vitro
   I. Introduction
   II. Intracellular Sites of RNA Synthesis
   III. Nuclear Sites of RNA Synthesis
   IV. The Biosynthesis of RNA Molecules
   V. Nucleic Acids of Mitochondria
   VI. RNA Synthesis in Special Cell Systems
   VII. RNA Synthesis over the Cell Cycle
   References
6. Turnover of Intracellular Proteins
   I. Introduction
   II. Proteins of the Nucleus
   III. Turnover of Proteins in Cytoplasmic Systems
   IV. Proteins and the Cell Cycle
   V. Protein Metabolism in Special Cell Systems
   References
7. The Dynamics of Extracellular and Cell Surface Protein Interactions
   I. Introduction
   II. Epigenetic Controls Regulating Differentiation: The Problem
   III. Outer Cell Surface Properties and Their Role in the Formation of Metazoan Systems
   IV. Epithelial-Mesenchymal Interactions
   V. The Extracellular Matrix Influences upon Cellular Differentiation
   References
8. Synthesis, Localization, and Renewal of Lipids in Mammalian Tissues
   I. Introduction
   II. Fatty Acids and Triglycerides
   III. Cholesterol
   IV. Sphingolipids
   V. Phospholipids
   VI. Brown Adipose Tissue
   VII. Summary
   References
9. Localization, Identification, and Renewal of Carbohydrates in Tissues and Cells
   I. Introduction
   II. Histochemistry of Mucins
   III. Histochemistry of Polysaccharides
   References
10. Calcification
    Text
    References
    Author Index
    Subject Index