Case Studies in Innovative Clinical Trials

Advances in technology and data infrastructure call for innovations in clinical trial design. This book will be an important showcase of the potential for these innovative designs in modern drug development and will be an important resource to guide those who wish to undertake them for themselves.

Auteur

Binbing Yu is a Senior Director in the Oncology Statistical Innovation group at AstraZeneca. He serves as the statistical expert across the whole spectrum of drug R&D, including drug discovery, clinical trials, operation and manufacturing, clinical pharmacology, oncology medical affairs and post-marketing surveillance. He obtained his PhD in Statistics from the George Washington University. His primary research interests are clinical trial design and analysis, cancer epidemiology, observational studies, PKPD modelling and Bayesian analysis. He has published three books on immunogenicity, cure modelling and RWD/RWE.

Kristine Broglio is a Statistical Science Director in the Astrazeneca Oncology Statistical Innovation group with interests in adaptive clinical trials and Bayesian statistics. She earned an MS in Biostatistics from the University of Washington and joined the University of Texas M.D. Anderson Cancer Center where she specialized in applied statistical analysis relating to the diagnosis, treatment, and long-term outcomes of breast cancer. Later at Berry Consultants, she led the design, execution, and analysis of well over 100 Bayesian adaptive and complex clinical trials. Ms Broglio is a member of numerous cross-industry working groups through the ASA and DIA and has contributed to over 120 papers to the medical and statistical literature.