Carcinogenesis: Fundamental Mechanisms and Environmental Effects

Proceedings of the 13th Jerusalem Symposium on Quantum Chemistry and Biochemistry held in Jerusalem, Israel, April 28-May 2, 1980

Contenu

Carcinogenicity of Polycyclic Aromatic Hydrocarbons: The Bay-Region Theory.- Inactivation of ØX174 and SV 40 Viral DNA Replication by Diol Epoxide Derivatives of Carcinogenic Polycyclic Hydro-carbons.- Dihydrodiols and Diol-Epoxides in the Activation and Detoxification of Polycyclic Hydrocarbons.- Metabolically Generated Free Radicals from Many Types of Chemical Carcinogens and Binding of the Radicals with Nucleic Acid Bases.- Nucleophilicity of DNA. Relation to Chemical Carcinogenesis.- An Analysis of the Reactivities of Epoxide Rings in Some Cyclic Hydrocarbons.- Biological Effects of Specific Hydrocarbon-DNA Reactions.- The Effect of Base Modification on Fidelity in Transcription.- Modification of DNA by Carcinogenic Aromatic Amines In Vivo and In Vitro with Possible Promutagenic Consequences.- Bio-chemical Considerations of the Enzymology Associated with Quinone and Tetrol Formation During Benzo (a) pyrene Metabolism.- Stereochemical Aspects of Benzo (a) pyrene Metabolism and Biochemical Individuality in Human Cells.- Metabolic and Structural Requirements for the Carcinogenic Potencies of Unsubstituted and Methyl-Substituted Polycyclic Aromatic Hydrocarbons.- Formation and Inactivation of DNA-Binding Metabolites of Benzo (a) pyrene Studied with Isolated Cells and Subcellular Fractions.- Enzymic Control of Reactive Metabolites from Aromatic Carcinogens.- Aflatoxin-DNA Interactions: Qualitative, Quantitative and Kinetic Features in Relation to Carcinogenesis.- Structural Modifications and Specific Recognition by Antibodies of Carcinogenic Aromatic Amines Bound to DNA.- Immunological Detection and Quantification of DNA Components Structurally Modified by Alkylating Carcinogens (Ethylnitrosourea)..- Characteristics of Stages of Hepatocarcinogenesis.- Mechanisms of Genetic Susceptibility to Cancer.- Constitutive Uncoupling of Pathways of Gene Expression that Control Growth and Differentiation and the Molecular Mechanism of Carcinogenesis.- Amplification of Carcinogenesis by Non-Carcinogens - Diterpene Type Promoters and Models of Environmental Exposure.- Reduction of Human Exposure to Environmental N-Nitrosocarcinogens. Examples of Possibilities for Cancer Prevention.- Endogenous Carcinogenesis: Nitrate, Nitrite and N-Nitroso Compounds.- Neoplastic Transformation, Somatic Mutation, and Differentiation.- Oncogenic Transformation, Initiation, Promotion and Mutagenesis in C3H/10T1/2 Cells.- Dissection of the Early Molecular Events in the Activation of Lymphocytes by 12-0- Tetradecanoylphorbol-13-acetate.- Modulation of Adipose Conversion of BALB/c 3T3 Cells by Tumor Promotors.- Established Cell Cultures as Model Systems for Carcinogen Metabolism.- Regulation of the Expression of SV40 T Antigen in Stem Versus Differentiated Cells.- The Effect of 12-0- Tetradecanoyl-phorbol-13-acetate (TPA) on Cell Transformation by Simian Virus 40 Mutants.- The Use of Cell Cultures to Assay the Effects of Chemicals on Bone Marrow.- Structural Modifications and Their Effects on the Genetic Functions of DNA Generated by Interactions with Benro (a) pyrene Metabolites.- Neoplastic Transformation of Human Mutant Cells by a Tumor Promoter.- Use of Human Epidermal Keratinocytes in Studies on Chemical Carcinogenesis.- Studies on Why 12-0-Tetra- decanoyl-phorbol-13-acetate (TPA) Does Not Promote Epidermal Carcinogenesis of Hamsters.- Modulation of Repair of DNA Damages Induced by Nitrosamines.- DNA Repair in Human Cells Exposed to Combinations of Carcinogenic Agents.- Reactions of Aflatoxin B1, Damaged DNA In Vitro and In Situ in Mammalian cells.- The Role of DNA Repair in Preventing the Cytotoxic and Mutagenic Effects of Carcinogens in Human Cells.- Transformation of Diploid Human Fibroblasts by Chemical Carcinogens.- Monoclonal Antibodies in the Study of Human Cancer.- Oculo-Cutaneous and Internal Neoplasmas in Xeroderma Pigmentosum: Implications for Theories of Carcinogenesis.- The Induction, Expression and Modulation of Radiation Induced Oncogenesis In Vitro in Diploid Humand and Rodent Cells.- Progress in Cloning the Transforming Gene from Chemically- Transformed Mouse Cells.- Relationship Between Transformation and Mutation in Mammalian Cells.- Membrane and Other Biochemical Effects of the Phorbol Esters and Their Relevance to Tumor Promotion.- The Chemistry of Poly- cyclic Aromatic Hydrocarbon-DNA Adducts.- Index of Subjects.