Cancer and Inflammation

How are cancer and inflammation interrelated mechanistically and clinically? Though extensive literature exists on the topic "Cancer and Inflammation", there are relatively few texts that have truly integrated the two in spite of the many common mechanisms shared by their processes. Certainly, areas such as cytokines, growth factors, proliferation, signal transduction and angiogenesis, for example, are found in both. Yet, the dynamics of how these common mechanisms are maybe interrelated in the pathologies of the two is not widely covered. Such coverage, as presented in this volume, may help further understanding and bring new approaches to therapeutics.

The first section of the book discusses inflammatory mechanisms, studied in cellular and animal studies. The second part concentrates on clinical studies with antiinflammatory drugs in cancer treatment. The volume is written for biomedical researchers in the health care industry and in academia who are working in these areas.

Contenu

Chronic inflammation and cancer in various organ systems.- Cancer as a chronic inflammatory disease: role of immunotherapy.- Inflammatory chemokines: their role in tumor growth and progression.- Inflammation and matrix metalloproteinases: implications for cancer development.- Interplay between inflammation and tumor angiogenesis.- Apoptotic responses common to cancer and inflammation.- Cyclooxygenase activity in gastrointestinal cancer development and progression: prospects as a therapeutic target.- Effects of COX-2 inhibitors in colorectal cancer.- Inflammation, necrosis, and cancer.