Organometallics in Synthesis

Provides detailed procedures and useful hints on
organometallic reactions of Cu, Rh, Ni, and Au

With contributions from leading organic chemists who specialize
in the use of organometallics in organic synthesis, this acclaimed
Manual offers an especially valuable resource for all
synthetic chemists, providing a practical reference for conducting
transition metal-mediated synthetic reactions. This Fourth
Manual is divided into four chapters:

• Chapter I: Organocopper Chemistry

• Chapter II: Organorhodium Chemistry

• Chapter III: Organonickel Chemistry

• Chapter IV: Organogold Chemistry

Each of these newly written chapters features detailed,
practical examples from the literature that guide readers through
the preparation of organometallic reagents and their applications
in organic synthesis. Procedures are presented in the
Manual's acclaimed step-by-step recipe format, enabling both
novices and experienced synthetic chemists to perform all the
reactions with ease. In addition, the Manual features:

• Extensive background information on the organometallic
  chemistry of Cu, Rh, Ni, and Au

• References to the primary literature facilitating further
  investigation of all the reactions covered in the
  Manual

• Mechanistic considerations to help readers better understand
  how the desired products are formed

• Future research opportunities for each organometallic
  class

Organometallics in Synthesis provides extensive and
detailed information enabling synthetic chemists to readily assess
the applicability of a synthetic method to a given need, and then
to perform the reaction with confidence. The Manual covers
both established organometallic procedures along with the most
recently published protocols.

Industrial processes are increasingly relying on organometallic
chemistry. In this Manual, readers will find applications to
such fields as natural products total synthesis, pharmaceuticals,
fine chemicals, biotechnology, agricultural science, polymers, and
materials science.

Auteur

BRUCE H. LIPSHUTZ is Professor of Chemistry at the
University of California, Santa Barbara. Much of Dr. Lipshutz's
scientific career has been dedicated to developing new reagents and
synthetic methodologies, especially those involving
organometallics. Among his many awards, Dr. Lipshutz has received
an Alfred P. Sloan Foundation Fellowship, Camille & Henry
Dreyfus Teacher-Scholar Award, an ACS Cope Scholar Award, the
Presidential Green Chemistry Challenge Award (2011), and the EROS
Best Reagent of the Year Award (2012).

Résumé

Provides detailed procedures and useful hints on organometallic reactions of Cu, Rh, Ni, and Au

With contributions from leading organic chemists who specialize in the use of organometallics in organic synthesis, this acclaimed Manual offers an especially valuable resource for all synthetic chemists, providing a practical reference for conducting transition metal–mediated synthetic reactions. This Fourth Manual is divided into four chapters:

• Chapter I: Organocopper Chemistry
• Chapter II: Organorhodium Chemistry
• Chapter III: Organonickel Chemistry

• Chapter IV: Organogold Chemistry
  Each of these newly written chapters features detailed, practical examples from the literature that guide readers through the preparation of organometallic reagents and their applications in organic synthesis. Procedures are presented in the Manual's acclaimed step-by-step recipe format, enabling both novices and experienced synthetic chemists to perform all the reactions with ease. In addition, the Manual features:

• Extensive background information on the organometallic chemistry of Cu, Rh, Ni, and Au
• References to the primary literature facilitating further investigation of all the reactions covered in the Manual
• Mechanistic considerations to help readers better understand how the desired products are formed
• Future research opportunities for each organometallic class
  Organometallics in Synthesis provides extensive and detailed information enabling synthetic chemists to readily assess the applicability of a synthetic method to a given need, and then to perform the reaction with confidence. The Manual covers both established organometallic procedures along with the most recently published protocols.

Industrial processes are increasingly relying on organometallic chemistry. In this Manual, readers will find applications to such fields as natural products total synthesis, pharmaceuticals, fine chemicals, biotechnology, agricultural science, polymers, and materials science.

Contenu

List of Contributors vii

Preface ix

Perspective xii
Prof. Dr. Reinhard W. Hoffmann

I Organocopper Chemistry 1
Bruce H. Lipshutz

II Organorhodium Chemistry 135
Iwao Ojima

III Organonickel Chemistry 317
John Montgomery

IV Organogold Chemistry 426
Norbert Krause

Index 547