Neoglycoconjugates

In recent decades, there has been an explosive growth in knowledge on the important biological roles of carbohydrates, especailly as specific information carriers. Neoglycoconjugates have been indispensable tools in these studies. This timely book, with both synthetic and application studies, will be of great value to researchers in a number of disciplines.

• Includes applications of neoglycoconjugates in medicine (vaccine preparation, drug targeting and tumor diagnosis)
• Is a comprehensive survey of synthetic strategies
• Covers application of neoglycoconjugates in basic research

Contenu

Introduction: Neoglycoconjugates: General Considerations
Enhanced Biochemical Affinities of Multivalent Neoglycoconjugates
Preparations: Synthesis of Neoglycoconjugates
Glycopeptide Synthesis
Use of Aminoalditols and Glycosylamines in Neoglycoconjugate Synthesis
Noncovalent Neoglycoproteins
Synthesis of Neoglycoconjugates Using Oliodacchiaride-Transferring Activity of Ceramide Glycanase
Carbohydrate-Containing Polystyrenes
Remodeling Glycopeptides for Affinity Labeling and Fluorescence Energy Transfer Studies
Applications: Synthetic Glycoconjugates as Human Vaccines
Hepatic Receptor Imaging Using Radiolabeled Asialoglycoprotein Analogs
Neoglycoproteins: Use in Tumor Diagnosis. Immobilized Glycoconjugates for Cell Recognition Studies
Neoganglioproteins: Probes for Endogenous Ganglioside Receptors
Drug Delivery Systems Using Carbohydrate Recognition
Determination of Epitope on Sugar Chains of Glycoproteins
Delivery of Polynucleotides to Hepatocytes