Bioactive Compounds from Marine Foods

Part of the IFT Press series, this book reviews the myriad
published information on bioactive components derived from marine
foods, enabling researchers and product developers to select
appropriate functional ingredients for new products.

Chapters cover foods and food ingredients from both animal and
plant marine sources, focusing on those which demonstrate
biological properties and whose constituent compounds have been
isolated and identified as potentially active. This book further
addresses the biological activities of PUFAs (Polyunsaturated fatty
acids), oils, phospholipids, proteins and peptides, fibres,
carbohydrates, chitosans, vitamins and minerals, fucoxantin,
polyphenols, phytosterols, taurine, amongst others. These
components, found in a variety of marine-derived foods, have been
demonstrated to have preventative properties with regard to
hypertension, oxidative stress, inflammation, cardiovascular
diseases, cancer and other human diseases.
Extraction methods and analysis techniques are also addressed.
Intended for food scientists, food technologists and food engineers
in academia, industry and government, this book reviews the
substantial quantity of current research in this fast-moving and
commercially valuable sector of food and nutrition science.

Auteur

About the editors

Dr Blanca Hernández-Ledesma Institute of Food Science
Research (CIAL, CSIC-UAM), Madrid, Spain

Dr Miguel Herrero Institute of Food Science Research (CIAL,
CSIC-UAM), Madrid, Spain

Résumé
Part of the IFT Press series, this book reviews the myriad published information on bioactive components derived from marine foods, enabling researchers and product developers to select appropriate functional ingredients for new products.

Chapters cover foods and food ingredients from both animal and plant marine sources, focusing on those which demonstrate biological properties and whose constituent compounds have been isolated and identified as potentially active. This book further addresses the biological activities of PUFAs (Polyunsaturated fatty acids), oils, phospholipids, proteins and peptides, fibres, carbohydrates, chitosans, vitamins and minerals, fucoxantin, polyphenols, phytosterols, taurine, amongst others. These components, found in a variety of marine-derived foods, have been demonstrated to have preventative properties with regard to hypertension, oxidative stress, inflammation, cardiovascular diseases, cancer and other human diseases. Extraction methods and analysis techniques are also addressed. Intended for food scientists, food technologists and food engineers in academia, industry and government, this book reviews the substantial quantity of current research in this fast-moving and commercially valuable sector of food and nutrition science.

Contenu

List of Contributors xvii

1 An Update on the Biomedical Prospects of Marine-derived Small Molecules with Fascinating Atom and Stereochemical Diversity 1
Yvette Mimieux Vaske and Phillip Crews

1.1 Introduction 1

1.2 A view based on atom diversity 11

1.3 A view based on stereochemical diversity 15

1.4 Case studies of chemical probes and chemical probes in the therapeutic discovery pipeline 20

1.5 Conclusion 21

Acknowledgments 21

References 21

2 Antihypertensive Peptides from Marine Sources 27
Roseanne Norris, P´adraig´ýn A. Harnedy, and Richard J. FitzGerald

2.1 Introduction 27

2.2 Marine antihypertensive peptides and blood pressure control 28

2.3 Generation of marine antihypertensive peptides 32

2.4 Structureactivity relationships 32

2.5 Bioavailability 33

2.6 In vivo animal studies 35

2.7 In vivo human studies 41

2.8 Marine peptides as antihypertensive ingredients 45

2.9 Conclusion 48

Acknowledgments 48

References 48

3 Bioactive Peptides from Marine Processing Byproducts 57
Maria Hayes and David Flower

3.1 Introduction 57

3.2 Fish muscle proteins: precursors of fish bioactive peptides 58

3.3 Fish meal production 59

3.4 Fish silage production 59

3.5 Traditional fermented fish protein products 60

3.6 Strategies for the generation of bioactive peptides from marine byproducts 60

3.7 Conclusion 66

Acknowledgments 67

References 67

4 Development of Marine Peptides as Anticancer Agents 73
Xiukun Lin and Lanhong Zheng

4.1 Introduction 73

4.2 Peptides that induce apoptosis 73

4.3 Peptides that affect the tubulinmicrotubule equilibrium 81

4.4 Peptides that inhibit angiogenesis 83

4.5 Peptides without a known mechanism for their antitumor activity 84

4.6 Conclusion 85

Acknowledgments 86

References 86

5 Using Marine Cryptides against Metabolic Syndrome 95
Yesmine Ben Henda and St´ephanie Bordenave-Juchereau

5.1 Marine cryptides 95

5.2 Definition of MetS 96

5.3 Potential targets for marine cryptides 97

5.4 Conclusion 108

References 108

6 Bioactive Phenolic Compounds from Algae 113
Yolanda Freile-Pelegr´ýn and Daniel Robledo

6.1 Introduction 113

6.2 Phenolic compounds from algae 116

6.3 Algal phenolics as bioactive compounds 120

6.4 Conclusion 122

Acknowledgments 124

References 124

7 Bioactive Carotenoids from Microalgae 131
A. Catarina Guedes, Helena M. Amaro, Isabel Sousa-Pinto, and F. Xavier Malcata

7.1 Introduction 131

7.2 Potential health benefits 131

7.3 Conclusion 144

Acknowledgments 144

References 145

8 Omega-3 Fatty Acid-enriched Foods: Health Benefits and Challenges 153
Charlotte Jacobsen

8.1 Introduction 153

8.2 Overview of the health benefits of marine omega-3 fatty acids 153

8.3 Lipid oxidation: a major challenge 155

8.4 Conclusion 168

References 168

9 Sterols in Algae and Health 173
Graciliana Lopes, Carla Sousa, Patr´ýcia Valentao, and Paula B. Andrade

9.1 Introduction 173

9.2 Biosynthesis of phytosterols 176

9.3 Analysis of phytosterols 179

9.4 Phytosterol composition of algae 181

9.5 Phytosterols and health 181

9.6 Conclusion 187

Acknowledgments 187

References 187 10 Biological Effects and Extraction Processes Used to Obtain Marine Chitosan 193<br /...