Biosynthesis of Antibiotics

Biosynthesis of Antibiotics, Volume I focuses on research conducted on the properties, compositions, and chemical reactions of antibiotics.
Composed of contributions of authors, the book discusses the microbial processes for the preparation of radioactive antibiotics. Areas of discussions include an introduction; microbial methods used in the preparation of radioactive antibiotics; and the presence of radioactive antibiotics prepared through microbial processes. The volume also focuses on the biosynthesis of penicillin and cephalosporins. Areas of interest include biosynthesis of penicillins; penicillin acylases; and cephalosporin C biosynthesis. The text also provides information on the biosynthesis of tetracycline antibiotics, streptomycin, and macrolide antibiotics. Numerical representations and schematic diagrams are presented to show the properties, compositions, and chemical reactions of antibiotics when exposed to varying conditions.
This volume is a great source of data for workers, graduate students, and faculties of biological sciences in the conduct of academic and industrial research.

Contenu

List of Contributors

Preface

1. Microbial Processes for the Preparation of Radioactive Antibiotics

   I. Introduction

   II. Microbial Methods Used in the Preparation of Radioactive Antibiotics

   III. Some Radioactive Antibiotics Prepared by Microbial Processes

   IV. Summary

   References

2. Biosynthesis of Penicillins and Cephalosporins

   I. Introduction

   II. Biosynthesis of Penicillins by Penicillium

   III. Penicillin Acylases

   IV. New Penicillins

   V. Penicillin Biosynthesis by Cephalosporium and Emericellopsis

   VI. Cephalosporin C Biosynthesis by Cephalosporium

   VII. Derivatives of Cephalosporin C (New Cephalosporins)

   VIII. Enzymes Which Act on Cephalosporin C

   IX. Hypothetical Pathway of Cephalosporin C and Penicillin Biosynthesis

   X. Summary

   References

3. Biosynthesis of Tetracycline Antibiotics

   I. Introduction

   II. General Considerations

   III. Origin of Carbon Atoms in the Tetracycline Molecule

   IV. Mechanisms and Intermediates

   V. Cell-Free Systems

   VI. Summary

   References

4. Biosynthesis of Streptomycin

   I. Introduction

   II. Biosynthesis of Streptidine

   III. Biosynthesis of 2-Deoxy-2-methylamino-L-glucose

   IV. Biosynthesis of Streptose

   V. Transglycosylation Reactions in the Formation of Streptomycin

   References

5. Biosynthesis of Polyacetylenes in Fungi

   I. Introduction

   II. Precursor Units

   III. Origin of Triple Bonds

   IV. Dynamics of Polyacetylene Synthesis

   V. Prospects

   References

6. Biochemistry of the Macrolide Antibiotics

   I. Introduction

   II. Structural Variation within the Macrolide Group

   III. Mechanisms Implicated in Macrolide Biogenesis

   IV. Sources of the Macrolide Precursors

   V. Biological Role of the Macrolides

   References

Author Index

Subject Index