Biomedical Materials and Diagnostic Devices

Biomedical Materials and Diagnostics Devices provides an up-to-date overview of the fascinating and emerging field of biomedical materials and devices, fabrication, performance, and uses

The biomedical materials with the most promising potential combine biocompatibility with the ability to adjust precisely the biological phenomena in a controlled manner. The world market for biomedical and diagnostic devices is expanding rapidly and the pace of academic research resulted in about 50,000 published papers in recent years. It is timely, therefore, to assemble a volume on this important subject.

The chapters in the book seek to address progress in successful design strategies for biomedical materials and devices such as the use of collagen, crystalline calcium orthophosphates, amphiphilic polymers, polycaprolactone, biomimetic assembly, bio-nanocomposite matrices, bio-silica, theranostic nanobiomaterials, intelligent drug delivery systems, elastomeric nanobiomaterials, electrospun nano-matrices, metal nanoparticles, and a variety of biosensors.

This large and comprehensive volume includes twenty chapters authored by some of the leading researchers in the field, and is divided into four main areas: biomedical materials; diagnostic devices; drug delivery and therapeutics; and tissue engineering and organ regeneration.

Auteur

Ashutosh Tiwari is an assistant professor of
nanobioelectronics at Biosensors and Bioelectronics Centre,
IFM-Linköping University, Sweden, as well as Editor-in-Chief
of Advanced Materials Letters. He has published more than
125 articles and patents as well as authored/edited books in the
field of materials science and technology.

Murugan Ramalingam is an associate professor of
biomaterials and tissue engineering at the Institut National de la
Santé et de la Recherche Médicale, Université de
Strasbourg (UdS), France. Concurrently, he holds an adjunct
associate professorship at Tohoku University, Japan. He has
authored more than 125 publications and is Editor-in-Chief of
Journal of Bionanoscience and Journal of Biomaterials and
Tissue Engineering.

Hisatoshi Kobayashi is group leader of Biofunctional
Materials at Biomaterials Centre, National Institute for Materials
Science, Japan. He has published more than 150 publications, books
and patents in the field of biomaterials science and technology, as
well as edited/authored three books on the advanced
state-of-the-art of biomaterials.

Professor Anthony P. F. Turner is currently Head of
Division, FM-Linköping University's new Centre for Biosensors
and Bioelectronics. His previous thirty-five-year academic career
in the United Kingdom culminated in the positions of Principal
(Rector) of Cranfield University and Distinguished Professor of
Biotechnology. Professor Turner has more than 600 publications and
patents in the field of biosensors and biomimetic sensors and is
best known for his role in the development of glucose sensors for
home-use by people with diabetes. He published the first textbook
on Biosensors in 1987 and is Editor-In-Chief of the principal
journal in his field, Biosensors & Bioelectronics, which
he cofounded in 1985.

Texte du rabat

Biomedical Materials and Diagnostics Devices provides an up-to-date overview of the fascinating and emerging field of biomedical materials and devices, fabrication, performance, and uses

The biomedical materials with the most promising potential combine biocompatibility with the ability to adjust precisely the biological phenomena in a controlled manner. The world market for biomedical and diagnostic devices is expanding rapidly and the pace of academic research resulted in about 50,000 published papers in recent years. It is timely, therefore, to assemble a volume on this important subject.

The chapters in the book seek to address progress in successful design strategies for biomedical materials and devices such as the use of collagen, crystalline calcium orthophosphates, amphiphilic polymers, polycaprolactone, biomimetic assembly, bio-nanocomposite matrices, bio-silica, theranostic nanobiomaterials, intelligent drug delivery systems, elastomeric nanobiomaterials, electrospun nano-matrices, metal nanoparticles, and a variety of biosensors.

This large and comprehensive volume includes twenty chapters authored by some of the leading researchers in the field, and is divided into four main areas: biomedical materials; diagnostic devices; drug delivery and therapeutics; and tissue engineering and organ regeneration.

Audience
This book is intended to be suitable for a wide readership including university students and researchers from diverse backgrounds such as chemistry, materials science, physics, pharmacy, biological science and bio-medical engineering. It can be used not only as a textbook for both undergraduate and graduate students, but also as a review and reference book for researchers in materials science, bioengineering, pharmacy, biotechnology and nanotechnology.

Contenu

Preface xv

Part I: Biomedical Materials

1. Application of the Collagen as Biomaterials 3
Kwangwoo Nam and Akio Kishida

1.1 Introduction 3

1.2 Structural Aspect of Native Tissue 5

1.3 Processing of Collagen Matrix 8

1.4 Conclusions and Future Perspectives 14

2. Biological and Medical Significance of Nanodimensional and Nanocrystalline Calcium Orthophosphates 19
Sergey V. Dorozhkin

2.1 Introduction 19

2.2 General Information on ?Nano? 21

2.3 Micron- and Submicron-Sized Calcium Orthophosphates versus the Nanodimensional Ones 23

2.4 Nanodimensional and Nanocrystalline Calcium Orthophosphates in Calcified Tissues of Mammals 26

2.5 The Structure of the Nanodimensional and Nanocrystalline Apatites 28

2.6 Synthesis of the Nanodimensional and Nanocrystalline Calcium Orthophosphates 34

2.7 Biomedical Applications of the Nanodimensional and Nanocrystalline Calcium Orthophosphates 47

2.8 Other Applications of the Nanodimensional and Nanocrystalline Calcium Orthophosphates 58

2.9 Summary and Perspectives 58

2.10 Conclusions 61

3. Layer-by-Layer (LbL) Thin Film: From Conventional To Advanced Biomedical and Bioanalytical Applications 101
Wing Cheung MAK

3.1 State-of-the-art LbL Technology 101

3.2 Principle of Biomaterials Based Lbl Architecture 102

3.3 LbL Thin Film for Biomaterials and Biomedical Implantations 103

3.4 LbL Thin Film for Biosensors and Bioassays 105

3.5 LbL Thin Film Architecture on Colloidal Materials 107

3.6 LbL Thin Film for Drug Encapsulation and Delivery 108

3.7 LbL Thin Film Based Micro/Nanoreactor 110

4. Polycaprolactone based Nanobiomaterials 115
Narendra K. Singh and Pralay Maiti

4.1 Introduction 115

4.2 Preparation of Polycaprolactone Nanocomposites 118

4.3 Characterization of Poly(caprolactone) Nanocomposites 119

4.4 Properties 123

4.5 Biocompatibility and Drug Delivery Application 141

4.6 Conclusion 150 Acknowledgement 150

5. Bone Substitute Materials in Trauma and Orthopedic Surgery ? Properties and Use in Clinic 157
Esther M.M. Van Lieshout

5.1 Introduction 158

5.2 Types of Bone Grafts 159

5.3 Bone Substitute Materials 161

5.4 Combinations with Osteogenic and Osteoinductive Materials 171

5.5 Discussion and Conclusion 173

6. Surface Functionalized Hydrogel Nanoparticles 191
Mehrdad Hamidi, Hajar Ashrafi and Amir Azadi

6.1 Hydrogel Nanoparticles 191

6.2 Hydrogel Nanoparticles Based on Chitosan 193

6.3 Hydrogel Nanoparticles Based on Alginate 194

6.4 Hydrogel Nanoparticles Based on Poly(vinyl Alcohol) 195

6.5 Hydrogel Nanoparticles Based on Poly(ethylene Oxide) and Poly(ethyleneimine) 196

6.6 Hydrogel Nanoparticles Based on Poly(vinyl Pyrrolidone) 198

6.7 Hydrogel Nanoparticles Based on P…