Biochemical Actions of Hormones V6

Biochemical Actions of Hormones, Volume VI is a 10-chapter text that summarizes the regulation of protein kinases and phosphoprotein phosphatases and the relationship of the endocrines to cancer.
This volume describes first the precise structures of steroid hormones and carcinogens. The subsequent chapters cover the hormonal regulation of chemical carcinogenesis; the importance of steroid hormones as growth factors for mammary tumors; the effects of steroid hormones in the central nervous system; and the properties of the purified estrogen receptor. A chapter highlights the biochemical actions of neurohypophysial hormones and neurophysin. Another chapter presents the biochemistry and physiology of cytokinin, a plant hormone. The final chapter exemplifies the multihormonal systems by control of the a2u-globulin produced in the liver.
This book will be of great value to endocrinologists.

Contenu

List of Contributors

Preface

Contents of Previous Volumes

1. The Physiological Regulation and Function of cAMP-Dependent Protein Kinases

   I. Introduction

   II. Properties of the cAMP-Dependent Protein Kinase

   III. Approaches for Evaluating the Function of cAMP-Dependent Protein Kinase: In Vitro and In Vivo Criteria

   IV. Specific Systems

   Addendum

   References

2. Hormonal and Metabolic Control of Phosphoprotein Phosphatase

   I. Introduction

   II. Enzyme Properties

   III. Hormonal Control

   IV. Conclusions

   References

3. Structural Aspects of Steroid Hormones and Carcinogenic Polycyclic Aromatic Hydrocarbons

   I. Structures of Steroids

   II. Biochemical Mechanisms Involving Steroids That Have Been Studied by Crystallographic Techniques

   III. Carcinogenic Polycyclic Aromatic Hydrocarbons and Their Structural Similarities to Steroids

   IV. Summary

   Appendix

   References

4. Modulation of Chemical Carcinogenesis by Hormones

   I. Introduction

   II. Mammary Gland

   III. Ovary

   IV. Liver

   V. Relationship of Binding Proteins (Enzymes) and Carcinogenesis

   VI. Conclusions

   Addendum

   References

5. How Important Are Steroids in Regulating the Growth of Mammary Tumors?

   I. General Comments on Mammary Tumor Growth

   II. Growth Characteristics of Human Breast Tumors

   III. Regulation of Cell Proliferation

   IV. Cell Loss

   V. Blood Supply

   VI. Cell-Cell Interaction

   VII. Immune Response to Breast Tumors

   VIII. Conclusions

   References

6. Biochemical Actions of Neurohypophysial Hormones and Neurophysin

   I. Introduction: Physiological Actions of Neurohypophysial Hormones

   II. Neurophysins

   III. Neurohypophysial Hormone-Receptor Interactions

   IV. Neurohypophysial Hormone Stimulus Generation

   V. Relationship between Stimulus Generation and Response

   VI. Molecular Events Mediating Neurohypophysial Hormone Action

   VII. Concluding Comments

   References

7. Biochemistry and Physiology of Cytokinins

   I. Introduction

   II. Effects of Physiological Processes

   III. Chemistry and Structure-Activity Relationships

   IV. Metabolism of Cytokinins

   V. Cytokinins in Nucleic Acids

   VI. Effects of Cytokinins on Metabolism

   VII. Concluding Remarks

   References

8. Steroid Hormone Receptors in the Central Nervous System

   I. Introduction

   II. Technical Aspects of Measuring Steroid Binding to Putative Receptors in Brain and Pituitary

   III. Neural and Pituitary Steroid Receptors in Relation to Function

   IV. Concluding Remarks

   References

9. Properties of Estrogen Receptor Purified to Homogeneity

   I. Introduction

   II. Purification to Homogeneity Estrogen Receptor

   III. Properties of Estrogen Receptor Purified to Homogeneity

   IV. Final Remarks and Conclusions

   References

10. Hormonal Regulation of a2u Globulin in Rat Liver

    I. Introduction

    II. Androgen-Dependent Synthesis of a2u Globulin and Its Modulation by Other Hormonal and Developmental Factors

    III. Cytoplasmic Androgen Binding Protein of Rat Liver and Its Possible Role in the Regulation of a2u Globulin

    IV. Messenger RNA for a2u Globulin and Its Regulation by Various Hormones

    V. Concluding Remarks

    References

Index