Biochemical Actions of Hormones V4

Biochemical Actions of Hormones, Volume IV explores the significant developments toward understanding the primary effects of hormones in cellular receptors at the molecular level.
This volume is composed of nine chapters, and begins with a review of the developments in affinity labeling that relate principally to the determination of the mechanisms of hormone action. The following chapters examine the role of prostaglandins in ovarian function and the methods for measuring protein synthesis and degradation in the heart and skeletal muscle. These topics are followed by discussions on the regulation of cholesterol synthesis by individual hormones; the regulatory mechanisms modulating the responsiveness of pineal gland to ß-adrenergic receptor stimulation; and the unitary mechanism of thyrotropin-releasing hormone action in target cells. The remaining chapters cover the insulin binding and insulin receptors from a variety of tissues and diverse species. These chapters also look into the physiology, molecular action, and biological effects of androgens and cyclic adenosine monophosphate.
This book will be of great benefit to endocrinologists.

Contenu

List of Contributors
Preface
Contents of Previous Volumes
Gordon M. Tomkins (1926-1975)

1. Affinity Labeling as a Technique in Determining Hormone Mechanisms
   I. Introduction
   II. Fundamental Considerations
   III. Steroid Binding Sites
   IV. Cyclic Nucleotides
   V. Protein Hormones
   VI. Other Hormonal Systems
   VII. Invertebrate Hormones
   VIII. Plant Hormones
   IX. Conclusion
   References
2. Mechanism of Prostaglandin Action in Endocrine Glands
   I. Introduction
   II. Prostaglandins in Ovarian Function
   References
3. Regulation of Protein Synthesis and Degradation in Heart and Skeletal Muscle
   I. Introduction
   II. Measurements of the Rate of Protein Synthesis
   III. Localization of the Effects of Metabolic and Hormonal Factors to Steps in the Synthetic Pathway
   IV. Measurement of Protein Degradation and Factors Affecting the Rate
   V. Nutritional Factors Regulating Protein Turnover
   VI. Role of Insulin in the Regulation of Protein Turnover
   VII. Concluding Remarks
   References
4. Hormonal Regulation of Cholesterol Synthesis
   I. Introduction
   II. Pancreas
   III. Pituitary
   IV. Thyroid
   V. Adrenals
   VI. Regulation by an Interplay of Hormones
   VII. Regulation via Feedback Repression
   VIII. Regulation of the Level of Cholesterol
   IX. Regulation in Relation to Cardiovascular Disease
   X. Perspective
   References
5. The ß-Adrenergic Receptor and the Regulation of Circadian Rhythms in the Pineal Gland
   I. Biosynthesis of Melatonin
   II. Circadian Rhythms in the Pineal Gland
   III. Conclusion
   References
6. Cell Culture Studies of Thyrotropin-Releasing Hormone Action
   I. Introduction
   II. GH Cells Produce Both Growth Hormone and Prolactin
   III. Are Both Prolactin and Growth Hormone Produced by a Single Cell?
   IV. Biological Responses of GH Cells to TRH
   V. The TRH Receptor
   VI. Unitary Hypothesis of TRH Action
   VII. Spare TRH Receptors-Multiple TRH Receptors
   VIII. Summary
   References
7. The Insulin Receptor: Properties and Regulation
   I. Introduction
   II. Indirect Studies
   III. Early Direct Studies
   IV. Properties of the Insulin Receptor
   V. Regulation of Insulin Bioactivity at the Receptor Level
   VI. Summary and Conclusions
   References
8. Molecular Actions of Androgens
   I. Introduction
   II. Evidence for Selective Androgen Retention in Target Tissue
   III. Cellular Localization and Multiple Forms of Androgen Receptors
   IV. Structural Recognition in Androgen-Receptor Interaction
   V. Transformation and Nuclear Retention of Androgen-Receptor Complex
   VI. Acceptor Molecules and Receptor-Nucleoprotein Interaction
   VII. Differential Action of Androgens and Universality of Receptors
   VIII. Some Biodynamic Aspects of Androgen Receptors
   IX. Mode of Action of Antiandrogens
   X. RNA Synthesis
   XI. Protein Synthesis
   XII. Concluding Remarks-Interaction of Metals and Nucleotides with Steroid Receptors
   References
9. Actions of Cyclic AMP and Its Relationship to Transmitter Function in Nervous Tissue
   I. Introduction
   II. Metabolism of Cyclic AMP and Its Regulation
   III. Cytochemical Localization of Cyclic AMP
   IV. Actions of Cyclic AMP
   V. Conclusions
   References
   Index