Biochemical Actions of Hormones V13

Biochemical Actions of Hormones, Volume XIII is a 13-chapter text that explores the biochemical aspects of polypeptide, steroid, and insect hormones.
The opening chapters examine the control of glucose transport by insulin, the participation of nuclear poly(adenosine diphosphate-ribosyl)ation in hormonal mechanisms, and the concept of ovulation control. These topics are followed by discussions on the immunohistochemistry of human chorionic gonadotropin; the adrenocorticotropic hormone (ACTH) action on adrenal cholesterol metabolism and its interaction with adrenal receptors; the structure-activity relationships of neurohypophyseal hormones; and the interactions between different functional sites in the epidermal growth factor receptor. A chapter focuses on the juvenile hormone-binding proteins. The remaining chapters consider the actions of steroid hormones. These chapters specifically describe the androgen receptor, the interaction of the glucocorticoid receptors with specific DNA sequences, and glucocorticoid actions on fibroblasts. A discussion on the potential role of RNA in the glucocorticoid receptor mechanism is also included in these chapters.
This book will be of great benefit to endocrinologists, biochemists, biologists, and researchers who are interested in hormonal action and regulation.

Contenu

Contributors
Preface

1. Mechanism of Insulin's Stimulatory Action on Glucose Transport in the Rat Adipose Cell
   I. Glucose Transport Activity in the Intact Cell
   II. Steady-State Subcellular Distribution of Glucose Transporters
   III. Characteristics of the Response to Insulin
   IV. The Translocation Hypothesis
   V. Counterregulation by Adenylate Cyclase Stimulators and Inhibitors
   VI. Chronic Regulation of the Response to Insulin
   VII. Summary
   References
2. Possible Participation of Nuclear Poly(ADP-ribosyl)ation in Hormonal Mechanisms
   I. Introduction
   II. Experimental
   III. Discussion
   IV. Summary
   References
3. Hormonal Control of Ovulation
   I. Introduction
   II. Oocyte Maturation
   III. Maturation of the Cumulus Oophorus
   IV. Luteinization
   V. Follicular Rupture
   VI. Concluding Remarks
   References
4. Immunochemistry of Human Chorionic Gonadotropin
   I. Introduction
   II. Chemistry of Human Chorionic Gonadotropin
   III. Immunochemistry of the hCGß Subunit Carboxy-Terminal Peptide Region
   IV. Regions of the hCG Surface Which Elicit Specific Immune Responses
   V. Application of Improved Methods for hCG Detection in Clinical Specimens
   VI. Use of Monoclonal Antibodies to Examine the Relationship between hCG Structure and Biological Activity
   References
5. The Mechanism of Action of Adrenocorticotropic Hormone on Cholesterol Metabolism in the Adrenal Cortex
   I. Introduction
   II. Overall Pathway of Glucocorticoid Synthesis from Adrenal Cholesterol
   III. Adrenocortical Cholesterol
   IV. Pathways of Adrenal Cholesterol Metabolism
   V. Summary
   References 159
6. Interaction of Corticotropin with Adrenocortical Cell Receptors
   I. Introduction
   II. Early Studies of ACTH Receptors
   III. Difficulties in Detecting ACTH Receptors
   IV. Synthesis of a Radioligand with Full Biological Potency
   V. Characterization of ACTH Receptors in Rat Adrenocortical Cells
   VI. ACTH Receptors in Human Adrenocortical Cells
   References
7. Structure-Activity of the Neurohypophyseal Hormones and Analogs and Implications for Hormone-Receptor Interactions
   I. Introduction
   II. Structures of the Neurohypophyseal Hormones
   III. Oxytocin Structure-Function Relationships
   IV. Vasopressin Structure-Function Relationships
   V. Concluding Remarks
   References
8. Interactions between Different Functional Sites in the EGF Receptor
   I. Introduction
   II. Mapping of the Functional Sites in EGF Receptor by Limited Proteolysis
   III. 42,000 Molecular Weight Fragment of EGF Receptor Has Protein Kinase Activity
   IV. Regulation of Kinase Catalytic Function by Receptor-Receptor Interaction and EGF-Induced Modulation of This Interaction
   V. Overall Picture and Relationship to the In Vivo Situation
   References
9. Juvenile Hormone-Binding Proteins
   I. Introduction
   II. Background
   III. Hemolymph JH-Binding Proteins
   IV. Intracellular JH-Binding Proteins
   References
10. Androgen Receptor Protein: Purification and Molecular Properties
    I. Introduction
    II. Steroid Binding Properties
    III. Purification of Androgen Receptor
    IV. Affinity Labeling of the Receptor
    V. Molecular Forms of the Receptor
    VI. Conclusions
    References
11. Interaction of the Glucocorticoid Receptor with Specific DNA Sequences
    I. Introduction
    II. Identification of Regions Necessary in Mouse Mammary Tumor Virus DNA for Hormone-Sensitive Transcription In Vivo
    III. Specific Sites on MMTV DNA Are Recognized by the Activated Glucocorticoid-Receptor Complex In Vitro
    IV. Correlation of Glucocorticoid Receptor-Binding Sites in the MMTV Proviral DNA with Hormone-Inducible Transcription
    V. DNA Footprinting Analysis of the Glucocorticoid Receptor-Binding Sites on the MMTV LTR
    VI. Interaction of Mutant Receptors and Antiglucocorticoid-Receptor Complexes with MMTV LTR Sequences
    VII. Hormone Inducibility Conferred by Sequences of Other Glucocorticoid-Inducible Genes
    VIII. The Glucocorticoid and the Progesterone Receptors Bind to the Same Sites in Two Hormonally Regulated Promoters
    IX. The Glucocorticoid-Responsive Element is a Transcriptional Enhancer
    X. Secondary DNA Structures in the Glucocorticoid-Dependent Enhancer Element
    XI. Conclusions
    References
12. Glucocorticoid Actions on Fibroblasts in Tissue Culture
    I. Introduction
    II. Fibroblast Models for the Study of the Mechanisms of Glucocorticoid Hormone Action
    III. Glucocorticoid Effects on Cellular Proliferation
    IV. Effects of Glucocorticoids on Glucose and Amino Acid Transport
    V. Protein Synthetic Effects of Glucocorticoids in Fibroblasts
    VI. Conclusion
    References
13. Association of RNA with the Glucocorticoid Receptor and Possible Role in Activation
    I. Introduction
    II. Association of RNA with Activated GR Complexes
    III. Association of RNA with Unactivated GR Complexes
    IV. Possible Role of an RNA in Receptor Activation
    V. Physiological Significance
    VI. Summary
    References
    Index