Biochemical Actions of Hormones V10

Biochemical Actions of Hormones, Volume X explores the important fields of recombinant DNA technology and nuclear matrix and their impact on biochemical endocrinology.
This volume is organized into 12 chapters and begins with a presentation of an excellent model for determining the role of various receptors operating at the genetic level using cells in culture derived from the anterior pituitary. These topics are followed by a summary of conceptual advances in understanding nerve growth factor and related hormones, as well as the polypeptide hormones, which are recognized as growth factors for cells in culture. A chapter provides some insights into the pineal hormone, melatonin. The remaining chapters discuss the Ah carcinogen receptor, which seems to be analogous in many respects to a steroid receptor. These chapters also survey the various aspects of steroid receptors, including the specific acceptor sites in genes and their flanking sequences, the synthetic oligonucloetide acceptors for steroid receptor complexes, and the mechanisms of glucocorticoid resistance in leukemia.
Biochemists, biologists, and research workers who are interested in biochemical aspects of endocrinology will find this book invaluable.

Contenu

Contributors

Preface

1. The Application of Recombinant Techniques to the Study of the Control of a2u Globulin Gene Expression

   I. Introduction

   II. Cloning

   III. The a2u Globulin Gene

   IV. DNA Methylation

   V. Salivary Gland a2u Globulin Synthesis

   References

2. The Role of the Nuclear Matrix in Steroid Hormone Action

   I. Introduction

   II. Isolation and Characterization of the Nuclear Matrix

   III. The Role of the Nuclear Matrix in DNA Replication

   IV. The Association of RNA with the Nuclear Matrix

   V. Regulation of DNA Structure on the Matrix

   VI. The Interaction of Steroid Hormones with the Nuclear Matrix

   VII. Fractionation of the Nuclear Matrix and Localization of Matrix-Associated Steroid Hormone Binding Sites

   VIII. Some Comments on the Nature of Nuclear Matrix-Associated Steroid Binding Sites

   IX. Potential Role of Cellular Structural Components in Hormone Action

   References

3. Nerve Growth Factor and Related Hormones

   I. Introduction

   II. The Relationship of Hormones and Growth Factors

   III. Nerve Growth Factor as a Hormone

   IV. Concluding Remarks

   References

4. Hormonal Regulation of Growth Hormone Synthesis in Cell Cultures: Role of Thyroid and Glucocorticoid Hormone Receptors

   I. Introduction

   II. Cell Culture Considerations

   III. Control of Growth Hormone Synthesis by Thyroid Hormone in Cultured Cells

   IV. Control of Growth Hormone Synthesis by Glucocorticoid Hormones in Cultured Cells

   V. Glucocorticoid Receptors in GH1 Cells: Physical Characteristics and Nature of the Activation (Transformation) Process

   VI. Concluding Remarks

   References

5. Factors Affecting Mammary Cells in Culture

   I. Introduction

   II. Methods to Culture Mammary Cells

   III. Mammogenic Hormones as Mitogens

   IV. Growth Factors and Nutrients

   V. Spatial Organization of the Cells and the Cell-Substratum Interaction

   VI. Discussion and Summary

   References

6. The Secretion and Actions of Melatonin

   I. Introduction

   II. The Mammalian Pineal Organ

   III. Melatonin

   IV. Summary

   References

7. The Ah Receptor: Controlling Factor in the Induction of Drug-Metabolizing Enzymes by Certain Chemical Carcinogens and Other Environmental Pollutants

   I. Introduction

   II. The Ah Locus

   III. Characteristics of the Ah Receptor

   IV. Future Directions

   V. Speculation on the Origin and Function of the Ah Receptor

   References

8. Specificity of Nucleic Acid Structure for Binding Steroid Receptors

   I. Introduction

   II. Biological Significance of DNA Binding of Steroid Receptors

   III. Separateness of Ligand- and DNA-Binding Domains

   IV. Recognition of DNA Structure by Steroid Receptors

   V. Nucleotide Base Recognition of Steroid Receptors

   VI. Potential Modulators of Steroid Holoreceptor: DNA Interaction

   VII. An Allosteric Model of Steroid Receptor: DNA Interaction

   References

9. Mammary Tumor Growth and Response to Ovariectomy

   I. Introduction

   II. Early Studies

   III. Estradiol Receptor as an Index of Hormonal Responsiveness

   IV. MTW9 Rat Mammary Tumor Model

   V. Growth Factors for Mammary Tumor Cells

   VI. Summary

   References

10. Hormonal Regulation of Estrogen and Progesterone Receptor Systems

    I. Introduction

    II. Methods

    III. Serum Steroid-Uterine Receptor Relationships

    IV. Progesterone Regulation of Nuclear Estrogen Receptor during the Estrous Cycle

    V. Estrogen Receptor Recovery in the Progesterone-Dominated Uterus

    VI. Summary and Conclusions

    References

11. Genetic and Biochemical Studies on Glucocorticoid-Induced Cleft Palate

    I. Introduction

    II. Normal Secondary Palatal Development

    III. Effect of Glucocorticoids

    IV. Genetics of the H-2 and H-3 Regions

    V. Biochemical Effects of Glucocorticoids

    VI. Glucocorticoids, Shelf Elevation, and Programmed Cell Death

    VII. Genetics of Clefting in Humans

    VIII. Summary

    References

12. Molecular Basis of Glucocorticoid Resistance in Experimental and Human Leukemia

    I. Introduction

    II. Glucocorticoid Effects on Corticoid-Sensitive Lymphocytes

    III. Resistance to Glucocorticoids in Animal Model Systems

    IV. Resistance to Glucocorticoids in Human Leukemia and Lymphoma

    V. Conclusions

    References

Index

Contents of Previous Volumes