Biochemical Actions of Hormones V1

Biochemical Actions of Hormones, Volume I explores the significant developments toward understanding the primary effects of hormones in cellular receptors at the molecular level. This book is composed of 12 chapters that survey the molecular and biochemical approaches bearing on the problem of hormone mechanism.
The opening chapters discuss the thyroid hormonal responses during metamorphic process in Amphibia; the primary role of hormones in biochemical differentiation; the influence of hormones on protein synthesis and the importance of protein synthesis mechanism; and the biochemical rhythms within the pineal gland and the rhythm in hepatic tyrosine transaminase activity. The subsequent chapters examine the effects of a number of hormones on transport systems in the cell membranes, the protein interaction with steroids, and the influence of insulin on protein and nucleic acid metabolism. The remaining five chapters deal with the physiology, mechanism of action, and biological effects of various hormones, such as mineralocorticoids, parathyroid hormone, calcitonin, thyrotropin, and plant hormones.
This book is an invaluable source for endocrinologists.

Contenu

List of Contributors
Preface

1. Hormonal Responses in Amphibian Metamorphosis
   I. Introduction
   II. Interrelationships of Hormones during Anuran Metamorphosis
   III. Changes in Blood
   IV . The Development of the Nervous System
   V. Responses of the Skin
   VI. Intestinal Development
   VII. Regression of the Pancreas
   VIII. Developmental Changes in the Liver
   IX. Tail Resorption
   X. Changes in Calcium and Bone Metabolism
   XI. Miscellaneous Effects
   XII. Some General Comments and Conclusions about Anuran Metamorphosis
   References
2. The Developmental Formation of Enzymes in Rat Liver
   I. Introduction
   II. Critical Stages of Enzymic Differentiation in the Liver
   III. The Late Fetal Stage
   IV. Neonatal Period
   V. Late Suckling Period
   VI. The Problems of the Mechanisms of Developmental Enzyme Formation
   VII. Biochemical Differentiation of Liver in Species Other Than Rat
   VIII. General Observations
   IX. Brief Summary
   References
3. Regulation of Protein Synthesis by Growth and Developmental Hormones
   I. Introduction
   II. Regulatory Mechanisms of Protein Synthesis in Animal Cells
   III. Hormones and Protein Synthesis
   IV. The Role of Cell Structure
   V. Phenomenology and Mechanism of Action
   References
4. The Regulation of Some Biochemical Circadian Rhythms
   I. Introduction
   II. Circadian Rhythms in the Pineal Gland
   III. Circadian Rhythm of Hepatic Tyrosine Transaminase Activity
   IV. Conclusions: Possible Driving Oscillations of Biochemical Rhythms
   References
5. Hormones and Transport across Cell Membranes
   I. Introduction
   II. Some Hormonal Effects on Transports
   III. Evidence that Hormones Affect Only One of the Transport Systems for Neutral Amino Acids
   IV. Concluding Remarks
   References
6. Binding of Hormones to Serum Proteins
   I. General Characteristics of Hormone-Protein Complexes
   II. Thyroid Hormone-Binding Proteins
   III. Steroid Hormone-Binding Proteins
   IV. Synopsis
   References
7. Insulin and Protein Synthesis
   I. Introduction
   II. General Effects of Insulin on Nitrogen Metabolism
   III. Protein Synthesis in Muscle
   IV. Accumulation of Amino Acids by Muscle
   V. Effect of Insulin on Labeling of Aminoacyl-tRNA
   VI. Insulin and RNA Metabolism in Muscle
   VII. Protein Synthesis in Subcellular Systems
   VIII. Summary and Conclusions
   References
8. Mineralocorticoids
   I. Historical Background
   II. Comparative Physiology
   III. The Induction Hypothesis
   IV. Role of Aldosterone-Induced Protein (AIP) in Mineralocorticoid Action
   V. The Oxidative Phosphorylation Hypothesis
   VI. Model of the Mechanism of Mineralocorticoid Action
   VII. Future Directions
   References
9. Parathyroid Hormone and Calcitonin
   I. Introduction
   II. Calcium Exchange in Cells and Subcellular Compartments
   III. Bone Cells and Their Function
   IV. Parathyroid Hormone, 3',5'-AMP, and Intracellular Calcium
   V. Mode of Action of Calcitonin
   VI. PTH, Vitamin D, and Intracellular Ca++
   VII. Summary and Conclusions
   References
10. Mechanism of Action of Thyrotropin
    I. Introduction
    II. The Specific Interaction of Thyrotropin with Thyroid Cellular Components
    III. Cyclic 3',5'-AMP as the Intracellular Mediator of Thyrotropin Action on the Thyroid
    References
11. The Thymus as an Endocrine Gland: Hormones and Their Actions
    I. Introduction
    II. Modern Concepts of the Thymus as an Endocrine Gland
    III. Chemistry and Actions of Thymic Fractions
    IV. Biological Effects of Thymic Extracts
    V. Summary
    References
12. Plant Hormones
    I. Introduction
    II. Auxins
    III. Gibberellins
    IV. Cytokinins
    V. Abscisic Acid
    VI. Ethylene
    References
    Author Index
    Subject Index