Asymmetric Synthesis V4

Asymmetric Synthesis, Volume 4: The Chiral Carbon Pool and Chiral Sulfur, Nitrogen, Phosphorus, and Silicon Centers describes the practical methods of obtaining chiral fragments. Divided into five chapters, this book specifically examines initial chiral transmission and extension.
The opening chapter describes the so-called chiral carbon pool, the readily available chiral carbon fragments used as building blocks in synthesis. This chapter also provides a list of 375 chiral building blocks, along with their commercial sources, approximate prices, and methods of synthesis. Schemes involving almost 1,300 structures and the use of chiral building blocks to prepare alkaloids, arachidonic acid metabolites, compounds with chemotherapeutic and pharmacological activity, insect pheromones, sugars, vitamins, terpenoids, and miscellaneous compounds are also included in this text. The remaining chapters provide a similar overview of the chemistry of compounds chiral at sulfur, phosphorus, nitrogen, and silicon.
Synthetic chemists and researchers, especially those engaged in pharmaceutical research and specialty chemicals production, will find this book invaluable.

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Contributors
Preface

1. Readily Available Chiral Carbon Fragments and Their Use in Synthesis
   I. The Method
   II. The Chiral Building Blocks
   III. Approaches to Synthetic Targets Using Chiral Carbon Building Blocks
   References
2. Optical Activation and Utilization of Compounds Containing Chiral Sulfur Centers
   I. Introduction
   II. The Optical Activation of Chiral Organosulfur Compounds
   III. Applications of Optically Active Organosulfur Reagents in Asymmetric Synthesis
   References
3. Preparation of the Enantiomers of Compounds Containing Chiral Phosphorus Centers
   I. Introduction
   II. Chiral Tertiary Phosphines and Related Substances
   III. Four-Coordinate Phosphorus Thioacids and Related Compounds
   IV. Conclusions
   References
4. Synthesis and Utilization of Compounds with Chiral Nitrogen Centers
   I. Introduction
   II. Chiral Trivalent Nitrogen
   III. Chiral Tetravalent Nitrogen
   References
5. Synthesis and Utilization of Compounds with Chiral Silicon Centers
   I. Introduction
   II. Mechanism of Reactions at Silicon
   III. Preparation of Optically Active Organosilanes
   IV. Utilization of Optically Active Organosilanes in Synthesis
   V. Concluding Remarks
   References
   Index