This book addresses the consequences of high agricultural pesticide use over the last few decades in the form of organophosphate poisoning. The authors provide a background overview of organophosphate compounds, their environmental toxicity, non-target exposures and cases of human poisoning. The authors also compile and analyze data from the last two decades to demonstrate the toxicological aspects of organophosphates, and how they can pose a threat to human health. Readers will learn about the clinical manifestation of organophosphate exposure in humans, as well as the enzymatic pathways and mechanisms by which organophosphates are processed in the body and cause harm. The book concludes by providing techniques, practices and recommendations for how to manage organophosphate exposure and poisoning. It will be useful for clinicians and public health professionals, scientists, medical practitioners, researchers and environmental toxicologists.

Auteur

Dr. Anuj Ranjan is an Assistant Professor at Amity Institute of Environmental Toxicology, Safety, and Management, Amity University, Noida, UP, India. Environmental Health is his major research area. He has worked on Organophosphate poisoning in humans and its risk assessment. His expertise includes structural bioinformatics, target characterization, molecular docking and simulation, and predictive toxicology. He has guided graduate and post-graduate students of Environmental Health Science students and is currently the supervisor of three Ph.D. Students. He has received awards from CSIR, Govt. of India, and the American Chemical Society (2016), and has presented his work at North American Chemical residue workshops (NACRW) (2017) in Naples, Florida, USA. He has also been a scientific member of the 34th Indian Scientific Expedition to Antarctica polar environment monitoring program of the Government of India.

Prof. Tanu Jindal completed her PhD in Ecotoxicology from Department of Zoology, University of Delhi in 1999. She is Group Additional Pro Vice Chancellor (R&D) and the Director of Amity Institute for Environmental Toxicology, Safety and Management (AIETSM) and Amity Institute of Environmental Sciences (AIES) at Amity University, Noida., UP, India. She is responsible for PhD, MSc. and B.Sc Environmental Science courses to promote environmental research and studies with syllabus covering important and current area of environmental science. She has filed six patents on lysimetric-device, apparatus to estimate the loss of xenobiotics by volatilization and mineralization, natural pesticide, photochemical method to dispose of dilute pesticide waste and cost-effective water testing kit. She has completed projects on Yamuna, Hindon, Ghagghar River ad groundwater contamination through pesticides, MoEF&CC; Contamination of soil and groundwater through leaching of drains in Delhi, MoES; Groundwater contamination of Chlorpyrifos in soils at different pH with CWRDM, DST; Environmental monitoring studies at Antarctica- NCAOR, Goa; Impact of Electro Magnetic Radiation- DST. Her recent initiatives are projects on Development of Lysimeter DST; Air Pollution Monitoring through CAAQMS-UPPCB; Development of Emission Factors, CPCB. Establishment of the Pesticide Referral Laboratory and MRL fixation of pulses and spices were her research endeavors at ICAR. Her expertise area is ISO-17025, GLP-studies, radio and stable isotope tracer techniques, GCMS and LCMS studies etc. She taught Pesticides Chemistry and Toxicology in Delhi University for 7 years to MSc students. She holds membership of eminent scientific societies. She has travelled extensively nationally and internationally presenting papers and has publications in referred journals of high impact factor. She has published more than 38 papers in reputed journals and has been serving as an editorial board member of repute. Editor of The Year Award 2017 by MTRES, Excellence in Research and Teaching Award 2017 by National Environmental Science Academy, prestigious Scientist of the year Award 2015, Environmentalist of the Year Award-2014 by NESA, New Investigator Award presentation at ACS, DST Young Scientist Award Project are to her credit. She has received travel awards from CSIR, DST & INSA.

Contenu

Chapter 1: Overview of organophosphate compounds.- Chapter 2: Toxicology of Organophosphate poisoning in humans.- Chapter 3: Enzymatic Targets of organophosphates.- Chapter 4: Computational insights of human acetylcholinesterase inhibition.- Chapter 5: New insights in Prophylactic approaches of human poisoning.- Chapter 6: Management of human Organophosphate poisoning.- Chapter 7: Summary.