Hormones

Hormones provides a comprehensive treatment of human hormones viewed in the light of modern theories of hormone action and in the context of current understanding of subcellular and cellular architecture and classical organ physiology.
The book begins with discussions of the first principles of hormone action and the seven classes of steroid hormones and their chemistry, biosynthesis, and metabolism. These are followed by separate chapters that address either a classical endocrine system, e.g., hypothalamic hormones, posterior pituitary hormones, anterior pituitary hormones, ,thyroid hormones, pancreatic hormones, gastrointestinal hormones, calcium regulating hormones, adrenal corticoids, hormones of the adrenal medulla, androgens, estrogens and progestins, and pregnancy and lactation hormones; or newer domains of hormone action which are essential to a comprehensive understanding of hormone action, including prostaglandins, thymus hormones, and pineal hormones. The book concludes with a presentation of hormones of the future, i.e., cell growth factors.
This book is intended for use by first-year medical students, graduate students, and advanced undergraduates in the biological sciences. It is also hoped that this book will fill the void that exists for resource materials for teaching cellular and molecular endocrinology and that it will be employed as an equal partner with most standard biochemistry textbooks to provide a comprehensive and balanced coverage of this realm of biology.

Auteur

Anthony W. Norman received his A.B. from Oberlin College in 1959, and an M.S. and Ph.D. in Biochemistry in 1961 and 1963, respectively, from the University of Wisconsin, Madison. Following postdoctoral work in Paul D. Boyer's group at UCLA, in 1964 he joined the Department of Biochemistry at University of California, Riverside, as an Assistant Professor. From 1976 to 1981 he served as Chair of the department and currently holds a Presidential Chair and is a Distinguished Professor of Biochemistry and Biomedical Sciences. Dr. Norman has also been active for some 25 years in medical education on the UC-Riverside campus and at UCLA through participation in the UR/UCLA Program in Biomedical Sciences, of which he was Dean and Director from 1986 to 1991.

Dr. Norman's biomedical research career has focused on the mechanism of action of the vitamin D family of steroids. His chief contributions to these areas of cellular and molecular endocrinology have played a pivotal role in defining the boundaries of this research domain via discoveries that have opened new areas of investigation. The first of these was the discovery in 1968, and chemical characterization in 1971, of the hormonally active form of vitamin D, 1a,25(OH)2-vitamin D3. Subsequent achievements include the discovery and characterization of the nuclear receptor for 1a,25(OH)2D3, the clinical evaluation of 1a,25(OH)2D3 in renal osteodystrophy, articulation of the concept of the vitamin D endocrine system, the importance of 1a,25(OH)2D3 to insulin secretion and the discovery of a new rapid, nongenomic, signal transduction process for 1a,25(OH)2D3.

Dr. Norman has been the recipient of awards that include a Fulbright Fellowship, 1970; Public Health Service Career Development Award, 1970; Mead Johnson Award, American Institute of Nutrition, 1977; Ernst Oppenheimer Award, Endocrine Society, 1977; Visiting Lecturer Australian Society of Endocrinology, 1978; Visiting Faculty Member, Mayo Clinic, 1981; Prix Andre.

Contenu

Preface
Chapter 1 General Considerations of Hormones
I. Classification of Hormones
II. Receptors for Hormones
III. Mechanisms of Hormone Action
IV. Evolution of Hormones
V. Physical Parameters of Hormone-Receptor Interactions
VI. Newer Developments Impacting on the Understanding of Hormone Action
VII. Summary
References
Chapter 2 Steroid Hormones: Chemistry, Biosynthesis, and Metabolism
I. Introduction
II. Chemistry of Steroids
III. Biosynthesis of Cholesterol
IV. Biosynthesis of Steroids
V. Properties of Enzymes Involved in Steroid Metabolism
VI. Catabolism and Excretion of Steroid Hormones
References
Chapter 3 Hypothalamic Regulating Hormones
I. Introduction
II. Anatomical, Morphological, and Physiological Relationships
III. Chemistry
IV. Biochemistry
V. Clinical Aspects
References
Chapter 4 Posterior Pituitary Hormones
I. Introduction
II. Anatomy, Development, and Fine Structure of the Posterior Pituitary
III. Chemistry
IV. Biochemistry
V. Biological and Molecular Actions
VI. Clinical Aspects
References
Chapter 5 Anterior Pituitary Hormones
I. Introduction
II. Anatomical, Morphological, and Physiological Relationships
III. Chemistry
IV. Biochemistry
V. Prolactin
VI. Growth Hormone
VII. ß-Lipotropin
VIII. Thyrotropic Hormone
IX. ACTH
X. Clinical Aspects
References
Chapter 6 Thyroid Hormones
I. Introduction
II. Anatomical and Morphological Relationships
III. Chemistry
IV. Biochemistry
V. Biological and Molecular Actions
VI. Clinical Aspects
References
Chapter 7 Pancreatic Hormones: Insulin and Glucagon
I. Introduction
II. Anatomical, Morphological, and Physiological Relationships
III. Chemistry
IV. Biochemistry
V. Biological and Molecular Actions
VI. Clinical Aspects
References
Chapter 8 Gastrointestinal Hormones
I. Introduction
II. Anatomical, Morphological, and Physiological Relationships
III. Chemistry and Biochemistry
IV. Biological and Molecular Actions
V. Clinical Aspects
References
Chapter 9 The Calcium-Regulating Hormones: Vitamin D, Parathyroid Hormone, Calcitonin
I. Introduction
II. Anatomical, Morphological, and Physiological Relationships
III. Chemistry and Biochemistry
IV. Biology and Physiological Significance
V. Clinical Aspects
References
Chapter 10 Adrenal Corticoids
I. Introduction
II. Anatomy, Development, and Cellular Fine Structure of the Adrenal Cortex
III. Chemistry and Biochemistry
IV. Biological and Molecular Actions
V. The Zona Reticularis and Dehydroepiandrosterone
VI. The Mineralocorticoid Hormone
VII. Clinical Aspects
References
Chapter 11 Hormones of the Adrenal Medulla
I. Introduction
II. Anatomical, Morphological, and Physiological Relationships
III. Chemistry
IV. Hormone Action and Biochemistry
V. Actions of Epinephrine
VI. Enkephalins
VII. Clinical Aspects
References
Chapter 12 Androgens
I. Introduction
II. Anatomical and Morphological Relationships of the Male Reproductive System
III. Chemistry, Biochemistry, and Biological Responses
IV. Physiological Relationships
V. Molecular Actions
VI. Clinical Aspects
References
Chapter 13 Estrogens and Progestins
I. Introduction
II. Anatomical and Morphological Relationships of the Female Reproductive System
III. Chemistry, Biochemistry, and Biological Responses
IV. Physiological Relationships
V. Biological and Molecular Actions
VI. Clinical Aspects
References
Chapter 14 Hormones of Pregnancy and Lactation
I. Introduction
II. Anatomical and Morphological Relationships
III. Chemistry, Biochemistry, and Biological Responses
IV. Cell Biology and Molecular Actions
V. Clinical Aspects
References
Chapter 15 Hormones of the Kidney
I. Introduction
II. Anatomical, Morphological, and Physiological Relationships
III. Homeostasis of Fluid, Electrolytes, and Blood Pressure
IV. Kallikreins and Kinins
V. Prostaglandins
VI. Erythropoietin
VII. Clinical Aspects
References
Chapter 16 Prostaglandins
I. Introduction
II. Chemistry
III. Biochemistry
IV. Biological Actions
V. Leukotrienes
VI. Clinical Aspe…