Angiotensin Vol. I

Nearly thirty years ago, in 1974, the volume on Angiotensin edited by Irvine H.Page and F. Merlin Bumpus expanded the Handbook of Experimental Pharmacology. Even after two decades the multiplicity of its actions appears not to have been fully discovered. To call attention to its many functions is one of the purposes of this book. This new edition of the volume on Angiotensin attempts to provide an updated account of the knowledge and findings accumulated since the complexity of angiotensin was so accurately recognized.

Contenu

Part 1: General Aspects.-General Physiology and Pathophysiology of the Renin-Angiotensin System. Phylogeny and Ontogeny of the Renin-Angiotensin System. Angiotensin as a Cytokine implicated in Accelerated Cellular Turnover. Regulation of Angiogenesis by Angiotensin II. Immunohistochemistry of Angiotensin. Renin-Angiotensin System: Plasma versus Tissues. Angiotensin-Endothelin Interactions.- Part 2: Genetics.- Genetics of the Human Renin-Angiotensin System. Knockout Models of the Renin-Angiotensin System. Transgenics of the RAS. Gene Therapy and the Renin-Angiotensin System.- Part 3: ANG Receptors.- AT1. AT1 Receptor Molecular Aspects. AT1 Receptor Interactions. AT1 Receptor Regulation. AT1 Receptor Signal Transduction. Sympathetic Interactions of AT1 Receptors. AT2.- Molecular Aspects of AT2 Receptor. AT2 Receptor of Angiotensin II and Cellular Differentiation. AT2 Renal Aspects. AT2 Function and Target Genes. AT1-7: Its Contribution to Arterial Pressure Control Mechanisms. Angiotensin AT4 Receptor.-