Intracellular Signal Transduction: The JAK-STAT Pathway

This book is the first one written about the JAK/STAT pathway. The JAK (Janus Kinase) Protein tyrosine kinases are novel phosphotransferases absolutely required for cellular signalling downstream of non-catalytic cytokine receptors (amongst others). These molecules are components in pathways utilising the STAT (Signal Transducers and Activators of Transcription) transcription factors. The basic components of the JAK/STAT pathway are covered in detail, and the centre piece of the book is a guided tour of the pathway itself. An interesting addition to the book is the chapter on the use of Drosophila melanogaster as a genetic system to probe the pathway at the whole organism level. The book is targeted to researchers who have an interest in intracellular signalling.

Contenu

1. Intracellular Signal Transduction.- 2. The Cytokine Receptor Family.- 3. The JAK Family of Protein Tyrosine Kinases.- 4. Signal Transducers and Activators of Transcription: The STAT Proteins.- 5. STFs: STAT-Containing Transcription Factors.- 6. Somatic Cell Genetic Dissection of Interferon Signal Transduction Pathways.- 7. A Guided Tour Through the JAK-STAT Pathway.- 8. Hopscotch/Tumorous Lethal: A JAK Family Member from Drosophila melanogaster.- 9. Future Trends.- References.