Transmembrane Dynamics of Lipids

The first and only book devoted entirely to MEMBRANE LIPID
ASYMMETRY AND ITS BIOLOGICAL IMPLICATIONS

Transmembrane Dynamics of Lipids is comprised of contributions
from expert authors from leading research groups that present
up-to-date quantitative data on the formation, stability, and
biological consequences of the asymmetrical organization of lipids
in cell membranes.

Incorporating an impressive amount of new, previously
uncollected data, the book examines transmembrane asymmetry and
movement of lipids in biological membranes, and methods for the
measurement of transmembrane lipid motion, emphasizing the role of
lipid flippases and discusses biological functions associated with
lipid asymmetry. In addition, it draws attention to important new
discoveries in the field, such as the correlation between
malfunction of lipid flippases and human diseases such as
thrombosis and cancer. The book also addresses the manifold methods
that are used to measure the rate of transmembrane movement of
lipids in biological and model systems.

The only guide to new discoveries regarding lipids in cell
membranes, Transmembrane Dynamics of Lipids is designed to appeal
to biophysicists, biochemists, and cellular and molecular
biologists working in the growing field of membrane research.

Auteur

Philippe F. Devaux, PhD, is Professor of Physics at the Paris 7
University.He has long-standing expertise in teaching molecular and
cellular biophysics and physics applied to biology and medicine. He
is the author of almost two hundred scientific papers and three
books, and is an Editor of the European Biophysics Journal.

Andreas Herrmann, PhD, is Professor of Molecular Biophysics at
Humboldt-University of Berlin. He teaches courses on the subjects
of molecular; cell; and membrane biophysics, optical spectroscopy,
and fluorescence microscopy. He is the author of more than two
hundred scientific papers focusing on lipid dynamics in biological
membranes and molecular mechanisms of virus infection.

Résumé
The first and only book devoted entirely to MEMBRANE LIPID ASYMMETRY AND ITS BIOLOGICAL IMPLICATIONS

Transmembrane Dynamics of Lipids is comprised of contributions from expert authors from leading research groups that present up-to-date quantitative data on the formation, stability, and biological consequences of the asymmetrical organization of lipids in cell membranes.

Incorporating an impressive amount of new, previously uncollected data, the book examines transmembrane asymmetry and movement of lipids in biological membranes, and methods for the measurement of transmembrane lipid motion, emphasizing the role of lipid flippases and discusses biological functions associated with lipid asymmetry. In addition, it draws attention to important new discoveries in the field, such as the correlation between malfunction of lipid flippases and human diseases such as thrombosis and cancer. The book also addresses the manifold methods that are used to measure the rate of transmembrane movement of lipids in biological and model systems.

The only guide to new discoveries regarding lipids in cell membranes, Transmembrane Dynamics of Lipids is designed to appeal to biophysicists, biochemists, and cellular and molecular biologists working in the growing field of membrane research.

Contenu

Introduction

List of Contributors.

Part I: ASSESSING TRANSMEMBRANE MOVEMENT AND ASYMMETRY OF
LIPIDS.

1. Methods for the Determination of Lipid Transmembrane
   Distribution and Movement in Biological Membranes (Philippe F.
   Devaux and Andreas Herrmann).

2. Detection and Measurement of Unlabeled Lipid Transmembrane
   Movement(Iván López-Montero, Marisela Vélez and
   Philippe F. Devaux).

Part II: LIPID ASYMMETRY IN CELL MEMBRANES.

3. New Insights in Membrane Lipid Asymmetry in Animal and Plant
   Cells (Alain Zachowski).

4. Sphingolipid Asymmetry and Transmembrane Translocation in
   Mammalian Cells (Gerrit van Meer, Sylvia Neumann, and Per
   Haberkant).

5. Transbilayer Movement and Distribution of Cholesterol
   (Peter Müller, Anna Pia Plazzo, and Andreas
   Herrmann).

Part III. ENERGY-INDEPENDENT PROTEIN-MEDIATED TRANSMEMBRANE
MOVEMENT OF LIPIDS.

6. Phospholipid Flip-Flop in Biogenic Membranes (Anant K.
   Menon and Andreas Herrmann).

7. Phospholipid Scramblase: When Phospholipid Asymmetry Goes
   Away (Edouard M. Bevers and Patrick L. Williamson).

Part IV: ENERGY-DEPENDENT LIPID TRANSPORT ACROSS
MEMBRANES.

8. Flip or Flop: Mechanism and (Patho)Physiology of
   P4-ATPase-Catalyzed Lipid Transport (Patricia M.
   Verhulst, Joost C.M. Holthuis, and Thomas G. Pomorski).

9. Coupling Drs2p to Phospholipid Translocation, Membrane
   Asymmetry, and Vesicle Budding (Xiaoming Zhou, Paramasivam
   Natarajan, Baby-Periyanayaki Muthusamy, Todd R. Graham, and Ke
   Liu).

10. Substrate Specifi city of the Aminophospholipid Flippase
    (Shelley M. Cook and David L. Daleke).

11. The Flippase Delusion? (Naomi L. Pollock, Petra H.M.
    Niesten, and Richard Callaghan).

Part V: RELEVANCE OF LIPID TRANSMEMBRANE DISTRIBUTION
FOR MEMBRANE PROPERTIES AND PROCESSES

12. Membrane Lipid Asymmetry and Permeability to Drugs: A Matter
    of Size (Adam Blanchard and Cyril Rauch).

13. Endocytosis and Lipid Asymmetry (Nina Ohlwein, Andreas
    Herrmann, and Philippe F. Devaux).

Part VI: APOPTOSIS AND DISEASES: CONSEQUENCES OF DISRUPTION
TO LIPID TRANSMEMBRANE ASYMMETRY

14. Membrane Lipid Asymmetry in Aging and Apoptosis
    (Krishnakumar Balasubramanian and Alan J. Schroit).

15. Phosphatidylserine Exposure in Hemoglobinopathies (Frans
    A. Kuypers and Eric Soupene).

16. Scott Syndrome: More Than a Hereditary Defect of Plasma
    Membrane Remodeling (Florence Toti and Jean-Marie
    Freyssinet).

17. ABCA1, Tangier Disease, and Lipid Flopping (Ana Zarubica
    and Giovanna Chimini).