An Information Technology Framework for Predictive, Preventive and Personalised Medicine

This book explores how PPPM, clinical practice, and basic research could be best served by information technology (IT). A use-case was developed for hepatocellular carcinoma (HCC). The subject was approached with four interrelated tasks: (1) review of clinical practices relating to HCC; (2) propose an IT system relating to HCC, including clinical decision support and research needs; (3) determine how a clinical liver cancer center can contribute; and, (4) examine the enhancements and impact that the first three tasks will have on the management of HCC. An IT System for Personalized Medicine (ITS-PM) for HCC will provide the means to identify and determine the relative value of the wide number of variables, including clinical assessment of the patient -- functional status, liver function, degree of cirrhosis, and comorbidities; tumor biology, at a molecular, genetic and anatomic level; tumor burden and individual patient response; medical and operative treatments and their outcomes.

Contenu

Preface.- Introduction.- The Digital Patient Model and Model Guided Therapy.- Hepatocellular Carcinoma and Patient Assessment.- Imaging in Hepatocellular Carcinoma: Radiologic Assessment.- Imaging in Hepatocellular Carcinoma: PET/CT.- Personalized Chemotherapy for Hepatocellular Carcinoma.- Surgical Treatment for Hepatocellular Carcinoma.- Minimally Invasive Therapies for Hepatocellular Cancer: Ablation Technologies.- Chapter 9 Minimally Invasive Therapies for Hepatocellular Cancer: Ablation Therapies.- Minimally Invasive Therapies for Hepatocellular Cancer:Catheter-Directed Therapies.- Radiation Oncology in the Treatment of Hepatocellular Carcinoma.- Design of an IT System for Hepatocellular Carcinoma.- Outlook and Expert Recommendations for Predictive, Preventive and Personalized Medicine and Hepatocellular Carcinoma.