Amine Oxidases: Function and Dysfunction

Monoamine oxidase plays a major role in the pathogenesis of neuropsychiatric disorders including depressive illness, Parkinson s disease and Alzheimer s disease. The new generation of selective monoamine oxidase inhibitors, devoid of major side effects, has found a prominent place in the treatment of these diseases. Some of these drugs may have neuroprotective activity with prospects for treating progressive neurodegenerative diseases. The volume presents a collection of research papers on monoamine oxidase and its inhibitors. The topic is treated from the point of view of chemistry, biochemistry, pharmacology, physiology, neurology and psychiatry. The book serves as a quick and comprehensive reference source for obtaining the most up to date information.

Contenu

Monoamine oxidase: structure.- Functional expression of C-terminally truncated human monoamine oxidase type A in Saccharomyces cerevisiae.- Kinetic properties of cloned human liver monoamine oxidase A.- Identification of human monoamine oxidase (MAO) A and B gene promoters.- Some problems associated with measuring monoamine oxidase activity in the presence of sodium azide.- Some kinetic properties of guinea pig liver monoamine oxidase.- Estimation of monoamine oxidase concentrations in soluble and membrane-bound preparations by inhibitor binding.- Monoamine oxidase: functions.- Monoamine oxidase and catecholamine metabolism.- Monoamine oxidase (MAO; E.C. 1.4.3.4) characteristics of platelets influenced by in vitro and in vivo ethanol on alcoholics and on control subjects.- The effects of ethanol on rat brain monoamine oxidase activities.- Species differences in changes of heart monoamine oxidase activities with age.- Age-related changes on MAO in B1/C57 mouse tissues: a quantitative radioautographic study.- The FAD dependent amine oxidases in relation to developmental state of enterocyte.- Role of monoamine oxidase and cathecol-O-methyltransferase in the metabolism of renal dopamine.- Comparison of the effect of reversible and irreversible MAO inhibitors of renal nerve activity in the anesthetized rat.- Chronic administration of the antidepressant phenelzine and its N-acetyl analogue: effects on GABAergic function.- Modification of cerebral cortical noradrenaline release by chronic inhibition of MAO-A.- Comparisons of the actions of high and low doses of the MAO inhibitor tranylcypromine on 5-HT2 binding sites in rat cortex.- Clorgyline effect on pineal melatonin biosynthesis in adrenalectomized rats pretreated with 6-hydroxydopamine.- Synergistic sedative effect of selective MAO-A, but not MAO-B, inhibitors and melatonin in frogs.- Clorgyline effect on pineal melatonin biosynthesis in roman high- and low-avoidance rats.- Reboxetine prevents the tranylcypromine-induced increase in tyramine levels in rat heart.- Monoamine oxidase inhibitors: effects on tryptophan concentrations in rat brain.- Deprenyl, MAO-B and neurodegenerative conditions.- Behaviour of (-)-deprenyl and its analogues.- Is selegiline neuroprotective in Parkinson's disease?.- Suppression of hydroxyl radical formation by MAO inhibitors: a novel possible neuroprotective mechanism in dopaminergic neurotoxicity.- Novel toxins and Parkinson's disease: N-methylation and oxidation as metabolic bioactivation of neurotoxin.- Amphetamine-metabolites of deprenyl involved in protection against neurotoxicity induced by MPTP and 2?-methyl-MPTP.- Is brain Superoxide dismutase activity increased following chronic treatment with 1-deprenyl?.- Lifespan of immunosuppressed NMRI-mice is increased by deprenyl.- Double blind cross over trial with deprenyl in amyotrophic lateral sclerosis.- Monoamine oxidase-B in motor cortex and spinal cord in amyotrophic lateral sclerosis studied by quantitative autoradiography.- The effect of 6-months l-deprenyl administration on pineal MAO-A and MAO-B activity and on the content of melatonin and related indoles in aged female Fisher 344N rats.- Reactive gliosis and monoamine oxidase B.- Monoamine oxidase inhibitors, cognitive functions and neurodegenerative diseases.- Newer monoamine oxidase inhibitors.- Can our knowledge of monoamine oxidase (MAO) help in the design of better MAO inhibitors?.- Kinetic behaviour of some acetylenic indolalkylamine derivatives and their corresponding parent amines.- Acetylenic and allenic derivatives of 2-(5-methoxy-l-methylindolyl)alkylamines as selective inhibitors of MAO-A and MAO-B.- Interactions between substituted tryptamine analogues, MAO inhibitors and cytochrome P-450.- Inhibition of monoamine oxidase by clorgyline analogues.- Kinetics of inhibition of MAO-B by N-(2-aminoethyl)-p-chlorobenzamide (Ro 16-6491) and analogues.- Experimental and theoretical study of reversible monoamine oxidase inhibitors: structural approach of the active site of the enzyme.- Lazabemide (Ro 19-6327), a reversible and highly sensitive MAO-B inhibitor: preclinical and clinical findings.- Food-derived hetero-cyclic amines, 3-amino-l,4-dimethyl-5H-pyrido[4,3-b]indole and related amines, as inhibitors of monoamine metabolism.- Chronopharmacological study of moclobemide effect on the rat pineal melatonin biosynthesis.- Biochemical pharmacology of befloxatone (MD370503), a new potent reversible MAO-A inhibitor.- Effects of befloxatone, a new potent reversible MAO-A inhibitor, on cortex and striatum mono-amines in freely moving rats.- The effects of brofaromine, a reversible MAO-A inhibitor, on extracellular serotonin in the raphe nuclei and frontal cortex of freely moving rats.- In vivo effects of the monoamine oxidase inhibitors Ro 41-1049 and Ro 19-6327 on the production and fate of renal dopamine.- Pharmacodynamics of MDL 72974A: absence of effect on the pressor response to oral tyramine.- The acute effect of the bioprecursor of the selective brain MAO-A inhibitor, MDL 72392, on rat pineal melatonin biosynthesis.- Chronic effect of the irreversible and reversible selective MAO-A inhibitors on rat pineal melatonin biosynthesis.- Semicarbazide-sensitive amine oxidases.- Properties of mammalian tissue-bound semicarbazide-sensitive amine oxidase: possible clues to its physiological function?.- Deamination of aliphatic amines by type B monoamine oxidase and semicarbazide-sensitive amine oxidase; pharmacological implications.- Haloallylamine inhibitors of MAO and SSAO and their therapeutic potential.- Several aspects on the amino oxidation by semicarbazide-sensitive amine oxidase (SSAO) from bovine lung.- Semicarbazide-sensitive amine oxidase activity of guinea pig dorsal skin.- Semicarbazide-sensitive amine oxidases in sheep plasma: interactions with some substrates and inhibitors.- Location of the active site of rat vascular semicarbazide-sensitive amine oxidase.- The ex vivo effects of procarbazine and methylhydrazine on some rat amine oxidase activities.- Histaminase activity of mesenteric artery of the rat.