Ultrastructure of Rat Adenohypophysis: Correlation with Function discusses the ultrastructure of the anterior pituitary in the normal intact rat, as well as in animal after various treatments and changes in its physiology. Wherever possible, the book attempts to coordinate and associate changes in pituitary ultrastructure with physiological aspects.
The book also presents a method for the isolation of various populations of pituitary secretory granules that can be used in experimental endocrinological research. It also discusses the various cell types, including the chromophobe; the pars tuberalis and pars intermedia of the adenohypophysis; and the chemical and physical properties of the secretory granules and their formation and release.
This reference will serve as a guide for pituitary ultrastructural studies in other species. It is valuable to students and experienced investigators in the field of endocrinology, anatomy, pathology, physiology, biochemistry, and related disciplines.

Contenu

Preface
Abbreviations and Terminology Used in Text
Abbreviations used in Electron Micrograph Descriptions
Chapter 1 Introduction
Text
References
Chapter 2 Experimental Procedures Animals
Preparation of Tissues for Electron Microscopic Study
Preparation of Pituitary Granules
Biological Assays
References
Chapter 3 Thyrotropes
Light Microscopy
Ultrastructure of Thyrotropes
Discussion
TSH Content of Pituitary Granule Fractions
References
Chapter 4 Gonadotropes
Light Microscopy of Gonadotropes
Ultrastructure of Gonadotropes
Discussion of Gonadotropes
FSH and L H Activity of Isolated Secretory Granule Fractions
References
Chapter 5 Adrenocorticotropes
Light Microscopy
Electron Microscopy
Metopirone
Amphenone
Dexamethasone
Adrenal Cortical Steroids
Exogenous ACTH
a-Ethyltryptamine
Corticotropes after Adrenalectomy and Castration
General Discussion of Corticotropes
Biological Activities of Pituitary Granule Fractions
References
Chapter 6 Somatotropes
Light Microscopy
Ultrastructure of Somatotropes
Discussion of Ultrastructural Findings
Somatotropic Activities of Granule Fractions
References
Chapter 7 Mammotropes
Light Microscopy
Ultrastructure of the Mammotrope in Intact and Treated Rats
Pituitary Autografts
References
Chapter 8 Chromophobes
Electron Microscopy of Chromophobes
References
Chapter 9 Pars Tuberalis
Histochemical Studies
Recent Histochemistry, Immunochemistry, and Electron Microscopy of the Pars Tuberalis
References
Chapter 10 Pars Intermedia
Hypophyseal Cleft
Cells of the Central Region of the Pars Intermedia
Cells of the Pars Intermedia after Pituitary Is Autografted to the Kidney Capsule
Other Hormones of the Pituitary Gland
References
Chapter 11 Hormonal Activities and Biochemical Properties of Isolated Granule Fractions
Biological Activities of Granule Fractions
Biochemical and Physical Properties of Granules
References
Chapter 12 Synthesis, Storage, and Release of Anterior Pituitary Hormones
Formation of Secretory Granules
Release of Pituitary Secretory Granules
Summary of Synthesis and Release of Anterior Pituitary Hormones
References
Author Index
Subject Index