Immunodiffusion

Cancer and Chemotherapy, Volume III: Antineoplastic Agents is a collection of articles that deals with the treatment of cancer using drugs. The collection describes the various drugs that are used, the therapeutic approaches being taken, and agents that are being developed.
Part I is a general review of anti-cancer drugs as regards their action mechanisms, pharmacokinetics, pharmacology, known toxicities, and clinical utility. These drugs include alkylating agents such as mitomycin C and nitrosoureas; plant alkaloids such as maytansine; antibiotics such as anthracyclines; platinum-containing complexes; antimetabolites; and hormones. Part II examines the molecular pharmacology of some major drug classes, namely, bleomycin and anthracycline. The text also discusses the chemistry, mechanism, and any structure-activity relationships found in these drug classes. Part III discusses in detail the clinical pharmacology of some antitumor drugs, for example, cisplatin and nitrosoureas. The text includes the clinical applications, biochemistry, metabolism, and the use of mathematical models in interpreting or describing resulting data.
The book is helpful for pharmacologists, molecular biologists, and scientists involved in cancer-research.

Contenu

Preface to the First Edition
Introduction

1. Basic Information
   Antiserum
   Antigens
   The Precipitin Reaction
   Other Serologic Reactions
   Diffusion
   Electrophoresis
   Other Methods of Reactant Migration
2. General Information
   Antiserum
   Antigen
   Immunization Protocols
   Collection and Care of Antiserum
   Nonantibody Precipitins
   Preparation of Antigens
   Media for Immunodiffusion
   Composition of Immunodiffusion Test Solvents
   Environmental Conditions for Immunodiffusion Tests
   Apparatus
   Reaction Enhancement
   Nonspecific Precipitation in Immunodiffusion Tests
   Washing and Staining Immunodiffusion Patterns
   Observing Recording, and Photographing Immunodiffusion Reactions
3. Single Diffusion Tests
   Mechanisms of Single Diffusion Tests
   Selected Single Diffusion Techniques
   Conclusion
4. Double Diffusion Tests
   Characteristics and Mechanisms
   Selected Double Diffusion Techniques
   Sensitivity of Double Diffusion Tests
5. Immunoelectrophoresis
   Theory and Interpretation of Immunoelectrophoresis
   Immunoelectrophoresis Techniques
6. Electroimmunodiffusion
   History
   Theory and Mechanisms
   Techniques
7. Ancillary Immunodiffusion Techniques
   Alternative Methods for Detecting Antigen-Antibody Reactions
   Auxiliary Indicators for Antigen-Antibody Reaction
   Novel Varieties of Immunodiffusion
8. History
   References
   Glossary
   Appendix I. Adjuvants
   Appendix U. Selected Immunodiffusion Electrolyte Solutions
   Appendix III. Selected Inmiunoelectrophoresis and Electroinmiunodiffusion Buffers
   Appendix IV. Immunochromatography Buffers
   Appendix V. Selected Protein Stains
   Appendix VI. Selected Lipid Stains
   Appendix VII. Selected Polysaccharide Stains
   Appendix VIII. Selected Nucleic Acid Stains
   Appendix IX. Selected Double Stains
   Subject Index