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Advances in the Biosciences 9 is a collection of presented papers on the International Conference on Prostaglandins, held in Vienna, Austria on September 25 to 28, 1972.
The book consists of 114 chapters of various topics in the field of prostaglandins. The meeting touches on several main topics such as new active analogs of prostaglandins; effect of aspirin and indomethasin and other compounds relative to the study of the role of the prostaglandins in the living organism; and the evaluation of the various analytical methods for the determination of the extremely minute amounts of prostaglandin occurring in the living organism.
Biologists, pharmacologists, endocrinologists, physicians, biochemists, and medical technologists will find the contents of this book invaluable.
Contenu
Introduction
Biosynthesis
Quantitative Aspects on Prostaglandin Synthesis in Man
Inhibition of Prostaglandin Biosynthesis
Catecholamine Induced Increase in Prostaglandin E Biosynthesis in Homogenates of the Rat Stomach Fundus
Comparative Aspects of Prostaglandin Biosynthesis in Animal Tissues
Metabolism
Structures of New Metabolites of Prostaglandin E2 in Man
Structures of C14 Metabolites of Prostaglandin F2a
Purification, Properties, and Biological Significance of Prostaglandin A Isomerase
Analytical Methods
Specific Antibodies: Reagents for Quantitative Analysis of Prostaglandins
Specificity of Prostaglandin Binding Sites in Rat Forestomach Tissue and Their Possible Use as a Quantitative Assay
Quantitative Mass Spectrometric Analysis of Prostaglandins
Differentiation between Endogenous and Exogenous (Administered) Prostaglandins in Biological Fluids
The Analysis of Prostaglandins Using a Computer for Plotting Ion Abundance Versus Time
Round Table Discussion on Analytical Methods
Biological Activity and Structure
The Synthesis and Biological Activity of a Series of 15-Methyl Prostaglandins
On the Prostaglandin Inhibitory Action of Polyphloretin Phosphate
Structure-Activity Relationship of Some Dibenzoxazepine Derivatives as Prostaglandin Antagonists
Relation of Prostaglandin Structure to Vascular Resistance in the Isolated Rat Pancreas
Metabolic Effects
The Regulatory Role of the Prostaglandins on the Cyclic 3', 5'-AMP System
Prostaglandins, Cyclic AMP, and Transformed Fibroblasts
Prostaglandins and Adenylcyclase System
Prostaglandin Production by Cells In Vitro
Metabolic Effects
Erythropoietic Effects of Prostaglandins
Prostaglandins and Sickle Cell Anemia
Inhibition of Vasopressin Action in Toad Bladder
Effects of Prostaglandin E1 and Arginine Vasotocin on Sodium Transport and Adenyl Cyclase Activity in Developing Tadpole Skin
Prostaglandin Modification of Membrane-Bound Enzyme Activity
Respiratory System
The Effects of Inhaled Prostaglandins on Bronchial Tone in Man
Opposite Effects of Prostaglandins E and F on Tracheal Smooth Muscles and Their Interaction with Calcium Ions
Comparative Studies on the Bronchodilating Properties of the Prostaglandin F2ß
The Regulatory Function of Prostaglandins in the Release of Histamine and SRS-A From Passively Sensitized Human Lung Tissue
Prostaglandin F2a: Effect on Airway Conductance in Healthy Subjects and Patients with Bronchial Asthma
Gastro-intestinal System
15-Methyl PGE2 and 16, 16-Dimethyl PGE2: Potent Inhibitors of Gastric Secretion
Effect of Orally and Intravenously Administered Prostaglandin 15 (R) 15-Methyl E2 on Gastric Secretion in Man
PGE2 and Gastric Acid Secretion in Man
The Relationship between Rat Gastric Mucosal Blood Flow and Acid Secretion during Oral or Intravenous Administration of Prostaglandins and Dibutyryl Cyclic AMP
Renal System
Introduction
A Histochemical Study of the Prostaglandin Biosynthesis in the Urinary System of Rabbit, Guinea Pig, Goldhamster, and Rat
Metabolic Mechanisms of Action of the Renal Prostaglandins
Effects of PGE2 on Renal Tubular Function
Prostaglandinlike Renal Vasodepressor Lipids and Electrolyte Exchange in the Kidney
The Effect of Prostaglandin (PGA1) on Adrenal Function in Man
Occurrence of Prostaglandins in Human Urine
Effect of PGE1 on Contrast Visualization of the Renal Vascular Bed: Comparison with Other Vasodilators
Inhibition of Prostaglandin Synthesis in the Kidneys by Aspirinlike Drugs
Synthesis of Prostaglandins (PGs) by Renomedullary Interstitial Cells (RIC) Grown in Tissue Culture
Circulatory System
Introduction
Effects of Prostaglandin E2 and F2a on Cutaneous Arteries and Veins In Vivo in the Isolated Rabbit Ear
Prostaglandin Induced Vasoconstriction of Cerebral Arteries and Its Reversal by Ethanol
Vasodepressor Action of Renomedullary Prostaglandins (PGE2 and PGA2) in the Spontaneously Hypertensive Rat (SH Rat): Evidence for a Central Action Mediated by the Vagus
Effect of Prostaglandin E1 on the Transmembrane Potentials of the Mammalian Heart
Effects of PGE1, PGE2, and PGF2a on Isolated Normal and Damaged Heart Preparations
Antiarrhythmic Properties of PGE2: Preliminary Results
Inflammation
Inhibition of Prostaglandin Biosynthesis as the Mechanism of Action of Aspirinlike Drugs
Arachidonic Acid and the Analgesic Action of Aspirinlike Drugs
Effect of Various Prostaglandins on Two Laboratory Models of Chronic Arthritic Inflammation
Prostaglandin Release in Ocular Inflammation in Rabbits and Man
Effect of Prostaglandin E1 on Lysosomal Enzyme Release from Human Leucocytes in the Presence of Dytochalasin B
Prostaglandins in Burn Injury
Antianaphylactic Effect of a Prostaglandin Antagonist, Polyphloretin Phosphate
The Effect of Prostaglandin E1 on the Production of Interferon
Prostaglandin E2 Biosynthesis in Human Skin: Subcellular Localization and Inhibition by Unsaturated Fatty Acids and Anti-inflammatory Agents
Nervous System
Prostaglandin Mediated Control of Sympathetic Neuroeffector Transmission
Prostaglandins on Cyclic-AMP Formation in Cerebral Cortex of Different Mammalian Species
Actions of Prostaglandin E1 on Spinal Neurons in the Frog
The Effects of Prostaglandin E2 on Conditioned Avoidance Response Behavior and the Electroencephalogram
Prostaglandin E1 and Endotoxin Fever, and the Effects of Aspirin, Indomethacin, and 4-Acetamidophenol
Effect of Prostaglandins E1 and F2a on Adrenergic Responses in the Pulmonary Circulation
15a. Termination of Pregnancy - Extra- and Intra-amniotic Administration of Prostaglandins
Termination of Pregnancy by Extraamniotic Prostaglandins and the Synergistic Action of Oxytocin
Induction of Abortion 1. by Intravenous and 2. by Intrauterine Administration of PGF2a (Extra- and Intraamniotic)
Intrauterine Administration of Prostaglandin F2a for Induction of Abortion
Therapeutic Abortion by Intraamniotic Administration of Prostaglandin F2a
Midtrimester Therapeutic Abortion Using Intraamniotic PGF2a
Induction of Abortion by Intraamniotic PGF2a: a Comparison of Dose Schedules
Intraamniotic Prostaglandin F2a for Midtrimester Abortion
Therapeutic Abortion by Intraamniotic Injection of Prostaglandins
15b. Termination of Pregnancy - Intravaginal Administration of Prostaglandins
Vaginal Administration of Prostaglandins to Induce Early Abortion
Postconceptional Fertility Control by Prostaglandins
Abortifacient Activity of Vaginally Administered Prostaglandin F2a
Prostaglandin F2a Vaginal Pessaries for Midtrimester Abortion
15c. Induction of Labor - Oral and Intravenous Administration of Prostaglandins
The Results of Using Prostaglandi…