Advances in Metabolic Disorders

Advances in Metabolic Disorders, Volume 6 covers the developments in the study of metabolic disorders. The book discusses the role of the skin in carbohydrate metabolism; the transmission of Alloxan diabetes and other diabetogenic influences; and the association between glucagon levels and diabetes mellitus. The text also describes the recent contributions to the study of diabetic angiopathy and neuropathy; the disorders due to enzyme defects in the red blood cell; and the pineal gland as a neuroendocrine inducer. The basic aspects of the biology and physiology of calcitonin in relation to its hitherto acknowledged significance in clinical metabolic disorders are also considered. Endocrinologists, biochemists, pharmacologists, physicians, physiologists and medical students will find the book invaluable.

Contenu

Contributors
Contents of Previous Volumes
The Role of the Skin in Carbohydrate Metabolism
I. Introduction
II. Properties of Skin
III. The Role of the Dermis in Glucose Homeostasis
IV. Carbohydrate Metabolism of the Epidermis
V. Sources of Energy in the Epidermis
VI. Glucose/Lactate Balance in the Intact Animal
VII. The Skin as an Indicator of Impaired Carbohydrate Metabolism
VIII. Concluding Remarks
Addendum
References
On the Transmission of Alloxan Diabetes and Other Diabetogenic Influences
I. Introduction-The Enigma of the Genetics of Human Diabetes
II. The Question of Spontaneous and Experimentally Induced Diabetes in Animals
III. Studies on Transmission of Experimental Diabetes Mellitus
IV. Induction and Transmission of Latent Diabetes
V. Pregnancy in Animals with Induced Carbohydrate Intolerance
VI. Plasma Insulin in Animals with Induced Diabetes
VII. Beta Cell Histology of Rats with Induced and Transmitted Diabetes
VIII. Interpretation of the Data
References
Glucagon and Diabetes Mellitus
I. Introduction
II. Normal Alpha Cell Function
III. Diabetic Ketoacidosis
References
Recent Contributions to the Study of Diabetic Angiopathy and Neuropathy
I. General Characteristics of Diabetic Angiopathy and Neuropathy
II. The Eye
III. The Kidney
IV. The Heart
V. The Extremities
VI. Capillary Resistance and Capillary Permeability
VII. Diabetic Neuropathy
VIII. Pathogenesis of Diabetic Angiopathy
IX. Pathogenesis of Diabetic Neuropathy
X. Prophylaxis and Therapy
References
Disorders Due to Enzyme Defects in the Red Blood Cell
I. General Considerations
II. Defects of the Embden-Meyerhof Pathway
III. Deficiencies in the Hexose Monophosphate and Related Pathways
IV. Other Enzyme Defects Associated with Hematologic Disease
References
The Pineal Gland-A Neuroendocrine Transducer
I. Introduction
II. Effects on the Reproductive System
III. Effects on the Adrenal Glands
IV. Effects on the Thyroid Gland
V. Effects on Growth and Growth Hormone
VI. Nonendocrine Effects
VII. Conclusions
References
Calcitonin in Metabolic Disorders
I. Calcitonin in the Scheme of Calcium Homeostasis
II. Nature of Calcitonin and Its Action
III. Clinical Considerations
IV. Summary
References
Author Index
Subject Index