Advances in Metabolic Disorders

Advances in Metabolic Disorders, Volume 1 presents the application of biochemistry to the pathogenesis of human diseases. This book discusses the parathormone physiology and its deviations, as well as the origins and course of osteoporosis.
The introductory chapters deal with the catabolism of glycogen; physiology of parathyroids; multiple enzymic defects; biochemical technology of glycogen storage disease; assay of parathyroid hormone; mechanisms of mitochondrial respiratory control; pathogenesis of primary osteoporosis; and nature of bone change. The subsequent chapters consider the definition and physiology of insulin antagonists and chemistry of parathyroid hormone. These topics are followed by discussions of the physiologic effects of aldosterone and the metabolic interrelationship between folate and vitamin B12 are presented. A chapter is devoted to the definition and treatment of hypoparathyroidism and hyperparathyroidism. The remaining chapters focus on the diagnosis of insulin antagonists in tissues, plasma, and serum.
The book can provide useful information to doctors, students, and researchers.

Contenu

Contributors
Preface
Glycogen Storage Disease
I. Introduction
II. The Catabolism of Glycogen
III. General Considerations on Glycogen Storage Disease
IV. Glycogenosis Related to a Phosphorylase Deficiency
V. Limit Dextrinosis (Defect of Amylo-1, 6-Glucosidase)
VI. Glycogenosis Related to the Absence of Glucose-6-Phosphatase
VII. Glycogenosis Related to the Absence of Acid Maltase (Pompe's Disease)
VIII. Amylopectinosis (Andersen's Disease)
IX. Multiple Enzymic Defects
X. Other Disturbances of Glycogen Metabolism
XI. Biochemical Technology of Glycogen Storage Disease
XII. General Discussion
References
The Parathyroids
I. Introduction
II. Physiology
III. Assay of Parathyroid Hormone
IV. Chemistry of Parathyroid Hormone
V. Biochemical Aspects of Parathyroid Hormone Action
VI. Hyperparathyroidism
VII. Hypoparathyroidism
References
Mitochondrial Respiratory Control: Biochemical PhysiologicalL, and Pathological Aspects Lars Ernster and Rolf Luft
I. Introduction
II. Biochemical Mechanisms
III. Physiological and Pathological Aspects
IV. Conclusions
References
Osteoporosis
I. Definition and Classification
II. Clinical Picture and Incidence
III. Diagnosis
IV. Nature of Bone Change
V. Pathogenesis of Primary Osteoporosis
VI. Secondary Osteoporosis
VII. Therapy
VIM. Conclusions
References
Basal Metabolic Rate and Thyroid Hormones
I. Introduction
II. The Determination of BMR
III. Thyroid Hormones and the Regulation of BMR
IV. Mode of Action of Thyroid Hormones
References
Insulin Antagonists and Inhibitors
I. Introduction: Definition and Physiological Insulin Antagonists
II. Insulin Antagonists in Tissues
III. Insulin Antagonists in Plasma and Serum
IV. Inhibitors of Glucose Uptake
V. Discussion and Implications
References
Aldosterone: Its Biochemistry and Physiology
I. Introduction
II. Biochemistry
III. Physiologic Effects of Aldosterone
IV. Abnormal Aldosterone Secretion in Disease and Its Implications
V. The Basic Problem: Mechanism for Normal Control of Aldosterone Secretion
VI. Could Angiotensin Be the Trophic Hormone for Aldosterone?
References
Foloc Acid Deficiency in Man and its Interrelationship with VitaminN B12 Metabolism
Part 1. Introduction
Part 2. General and Historical Survey
I. Historical Review of the Relationship of Folic Acid and Vitamin B12 to the Megaloblastic Anemias
II. Distribution, Chemistry, and Absorption of Food Folate
III. The Metabolic Functions of the Folate Coenzymes
IV. The Interrelationships of the Folate Coenzymes
V. Metabolic Reactions of Vitamin 812 and Site of Interaction with Folate in Mammals
Part 3. Methodology
I. Cytological Criteria of Megaloblastic Anemia
II. The Therapeutic Trial As an Index of Specific Deficiency
III. Newer Methods to Evaluate the Intermediary Metabolism and Physiology of Folates
Part 4. Appraisal of Folate Deficiency and Metabolism in Megaloblastic
Anemias and Other Clinical Disorders
I. Clinical Diagnostic Experience with Various Parameters of Folate Deficiency
II. Incidence of Folate Deficiency
III. Nutritional Requirement and Metabolic Turnover of Folate
IV. Metabolic Interrelationship between Folate and Vitamin
References
Addendum to the Paper "Glycogen Storage Disease"
Author Index
Subject Index